血清Cys C、β_2-m、α_1-m和尿mAlb联检对妊娠期高血压疾病早期肾损伤的诊断价值

Diagnostic Value of Combined Measurement of Serum CysC,β_2-m,α_1-m and Urinary Microalbumin Levels in Pregnancy Induced Hypertension Patients with Early Kidney Injury

目的:探讨胱抑素C(CysC)、β2微球蛋白(β2-m)、α1-微球蛋白(α1-m)和尿液微量白蛋白(mAlb)联检对妊娠高血压疾病早期肾损害的临床评价。方法:应用胶乳免疫增强比浊法和生化法对48例妊娠高血压疾病早期患者进行了血清CysC、β2-m、α1-m和尿液mAlb检测并与35名正常孕妇作比较。结果:以单一指标阳性作为诊断标准,CysC、β2-m、α1-m和mAlb对妊娠高血压疾病肾损害的敏感性分别为83.2%、63.5%、58.4%、81.2%,特异性分别为88.5%、67.2%、60.8%、85.6%,联检两项或两项以上阳性作为标准,本文患者诊断的灵敏度为95.6%,特异性为96.8%。可导致统计学上有意义的表达。结论:联检CysC、β2-m、α1-m和mAlb对妊娠高血压疾病早期肾损害的辅助诊断有较高的临床实用价值。

Objective To observe the diagnostic value of combined measurement of serum CysC,β2-m,α1-m and umAlb levels in pregnancy induced hypertension patients with early kidney injury.Methods Serum CysC（with latex-enhanced immunoturbidimetry）,β1-m,α1-m and umAlb（with biochemistry） levels were determined in 48 patients with early impaired renal function in patients hypertensive disorders complicating pregnancy and 35 normal controls.Results As a single positive marker for diagnosis,the sensitivity for serum CysC,β2-m,α1-m and umAlb were 83.2%,63.5%,58.4% and 81.2% respectively,the specificity were 88.5%,67.2%,60.8% and 85.6% individually with combined detection of the four markers and assuming two or more markers positive as standard,the sensitivity was 95.6% and specificity was 96.8%,induced as stastically significant expression.Conclusion Combined measurement of serum CysC,β2-m,α1-m and umAlb levels has clinical value for diagnosis in pregnancy induced hypertension patients with early kidney injury.