再生障碍性贫血患者接受免疫抑制治疗发生致死性CMV肺炎一例报告并文献复习
摘要
巨细胞病毒感染(Cytomegalovirus infection,CMVI)和CMV病(Cytomegalovirus disease,CMVD)是接受造血干细胞移植和实体器官移植患者的常见并发症和重要死亡原因。近年,随着新型免疫抑制剂的应用,非移植治疗患者发生CMV活化的机会也明显增加,但迄今尚无重型再生障碍性贫血(SAA)患者接受免疫抑制治疗(IST)而罹患致死性CMVI的报告。我们收治1例SAA患者采用兔源抗胸腺细胞球蛋白(r—ATG)联合环孢素(CsA)治疗,患者发生严重CMVI并死亡,现报告如下。
出处
《中华血液学杂志》
CAS
CSCD
北大核心
2011年第12期867-869,共3页
Chinese Journal of Hematology
参考文献15
-
1Ljungman P, Griffiths P, Paya C. Definitions of cytomegalovirus infection and disease in transplant recipients. Clin Infect Dis, 2002, 34: 1094-1097.
-
2Bacigalupo A. Antilymphocyte/thymocyte globulin for graft versus host disease prophylaxis: efficacy and side effects. Bone Marrow Transplant, 2005, 35: 225-231.
-
3Scheinberg P, Fischer SH, Li L, et al. Distinct EBV and CMV re- activation patterns following antibody-based immunosuppressive regimens in patients with severe aplastic anemia. Blood, 2007, 109 : 3219-3224.
-
4Gaber AO, First MR, Tesi RJ, et al. Results of the double-blind, randomized, multicenter, phase Ⅲ clinical trial of thymoglobulin versus Atgam in the treatment of acute graft rejection episodes after renal transplantation. Transplantation, 1998, 66: 29-37.
-
5Brennan DC, Flavin K, Lowell JA, et al. A randomized, double- blinded comparison of Thymoglobulin versus Atgam for induction immunosuppressive therapy in adult renal transplant recipients. Transplantation, 1999, 67: 1011-1018.
-
6Atta EH, Dias DS, Marra VL, et al. Comparison between horse and rabbit antithymocyte globulin as first-line treatment tbr patients with severe aplastic anemia: a single-center retrospective study. Ann Hematol, 2010, 89 : 851-859.
-
7Baumann H, Judith D, Zey C, et al. Antithymocyte globulin Fre- senius or San gstat (Genzyme) as part of the conditioning for unre- lated donor HSCT: emerging differences in post-transplant immune reconstitution. Bone Marrow Transplant, 2004, 33 : s51.
-
8Terasako K, Sato K, Sato M, et al. The effect of different ATG preparations on immune recovery after allogeneic hematopoietic stem cell transplantation for severe aplastic anemia. Hematology, 2010, 15: 165-169.
-
9Ducloux D, Kazory A, Challier B, et al. Long-term toxicity of an- tithymocyte globulin induction may vary with choice of agent: a single- center retrospective study. Transplantation, 2004, 77 : 1029-1033.
-
10Scheinberg P, Nunez 0, Wu C, et ah Treatment of severe aplas- tic anaemia with combined immunosupprcssion: anti-thymocyte globulin, ciclosporin and mycophenolate mofetil. Br J Haematol, 2006, 133 : 606-611.
-
1白玉盛,李晓征.重型再生障碍性贫血患者中医证型分布及其与疗效的相关性[J].中医杂志,2011,52(7):562-563.
-
2刘媛,秦晶,彭昳.护理干预在重型再生障碍性贫血患者预防感染中的应用[J].吉林医学,2010,31(34):6363-6364. 被引量:5
-
3杨益莲,丁家华,余正平,何文多.造血干细胞移植治疗重型再生障碍性贫血患者21例[J].中华器官移植杂志,2016,37(5):309-310.
-
4逯秀玲,王昕,王雯,王红艳,邵宗鸿.ALG/ATG治疗重型再生障碍性贫血后血清病皮疹的观察及护理[J].天津护理,1999,7(6):236-237.
-
5李星鑫,王敏,邵英起,聂能,施均,黄振东,张静,葛美丽,黄金波,郑以州.免疫抑制治疗后合并血流感染的重型再生障碍性贫血患者临床特征及预后分析[J].中华血液学杂志,2016,37(9):807-812. 被引量:5
-
6刘庆国,王慧君,张莉,张丽红,庞爱明,储榆林,张凤奎.骨髓造血衰竭伴先天性角化不良一例[J].中华血液学杂志,2008,29(7):463-463.
-
7李彦希,郭在培.他克莫司治疗异位性皮炎6例临床观察[J].华西医学,2007,22(1):143-143.
-
8邵宗鸿.重视重型再生障碍性贫血患者感染的预防与治疗[J].中华血液学杂志,2012,33(3):161-162. 被引量:13
-
9陈育红,赵晓甦,刘开彦,许兰平,刘代红,陈欢,张晓辉,韩伟,王昱,赵婷,赵晓涛,黄晓军.造血干细胞移植后患者血浆巨细胞病毒DNA拷贝数与巨细胞病毒病的关系[J].中华医学杂志,2009,89(22):1540-1543. 被引量:6
-
10刘威.预见性护理在重型再生障碍性贫血患者中的应用[J].吉林医学,2017,38(2):397-398. 被引量:3