医院鮑曼不动杆菌的耐药趋势及临床分布特征分析

Analysis of clinical distribution and drug-resistance of Acinetobacter Baumannii

目的了解雅安地区医院鲍曼不动杆菌的耐药趋势及临床分布特征。方法 385株鲍曼不动杆菌按常规方法进行培养和分离,获得菌株在VITEK-32中进行鉴定及药敏试验,用绿脓假单胞(ATCC27853)及大肠埃希氏(ATCC25922)菌株作药敏质控菌株。结果检测出的385株鲍曼不动杆菌分布于11个科室,其中重症监护病房(ICU)185例,神经内科65例,呼吸感染科42例,血液科15例,肾内科30例,普外科19,胸外科12例,内分泌科8例,其他科室9例。385株鲍曼不动杆菌对测试的8种抗菌药物中,头孢哌酮/舒巴坦、美罗培南、亚胺培南的耐药率分别为9.2%、16.5%、21.8%。结论医院鲍曼不动杆菌临床分布较广,感染率呈上升趋势,测试的8种抗菌药物中,头孢哌酮/舒巴坦、美罗培南、亚胺培南的耐药率低,可作为鲍曼不动杆菌感染的选择抗菌药物。

Objective To investigate the clinical distribution and drug resistance of Acinetobacter baumannii in local hospitals.Methods 385 strains of Acinetobacter baumannii according to conventional Methods were isolated.The identification and susceptibility test of strains can be obtained in VITEK-32 with Pseudomonas aeruginosa（ATCC27853） and Escherichia coli（ATCC25922） strains for susceptibility of strains＇ quality control.Results 385 strains of Acinetobacter baumannii were detected to be found in 11 sections,185 cases in intensive care unit（ICU）,65 cases in mentally medicine,42 cases in respiratory infections Division,15 cases in Department of Hematology,30 cases in renal medicine,19 cases in general surgery,12 cases in thoracic surgery,8 cases in Endocrinology and 9 cases in other departments.Among the 8 antimicrobial agents tests to 385 strains of Acinetobacter baumannii,resistance rates of the cefoperazone / sulbactam,meropenem,imipenem were 9.2%,16.5%,21.8%.Conclusion Clinical Acinetobacter baumannii is wide distribution and the infection rates rise.The resistance rates of the cefoperazone / sulbactam,meropenem,imipenem were low.