南海海绵Rhabdastrella globostellata化学成分的研究

STUDIES ON THE CHEMICAL CONSTITUENTS OF THE MARINE SPONGE RHABDASTRELLA GLOBOSTELLATA FROM SOUTH CHINA SEA

从中国南海海绵Ｒｈａｂｄａｓｔｒｅｌｌａ ｇｌｏｂｏｓｔｅｌｌａｔａ中分离到四个有机化合物，经紫外光谱（ＵＶ），红外光谱（ＩＲ），质谱（ＭＳ）和核磁共振谱（１ＨＮＭＲ，１３ＣＮＭＲ，２ＤＮＭＲ和ＮＯＥＳＹ）等方法确定它们的化学结构分别为：２５（２９）－亚甲基－２６－甲基－２６－乙基胆甾醇（Ⅰ），（１３Ｅ，１５Ｅ，１７Ｅ，２２Ｅ，２４Ｅ）－３，１２－二氧－１３，１５，１７，２２，２４－五烯－２６－异臭椿酸（Ⅱ），β－吲哚酸（Ⅲ）和尿嘧啶（Ⅳ）。其中，化合物（Ⅰ）和化合物（Ⅱ）是新化合物，化合物（Ⅰ）通过乙酰化反应获得化合物（Ⅴ），化合物（Ⅱ）通过重氮化反应获得化合物（Ⅳ）。

Four organic compounds were isolated from the marine sponge Rhabdastrella globostellata from South China Sea. Their chemical structures were identified by UV, IR,MS, HRMS, ~1HNMR, ~13 CNMR, ~2DNMR etc. as: 25 (29 )-methylene-26-methyl-26-et (Ⅰ), (13E, 15E, 17E, 22E, 24E )-3, 12-dioxoisomalabarica-13, 15, 17, 22, 24-pentaen-26-oic acid (Ⅱ),β-indole carboxylic acid (Ⅲ), uracil (Ⅳ). Compound (Ⅰ) and (Ⅱ) are new com pounds. 25 (29)-methylene-26-methyl-26-ethylcholesterol acetate(Ⅳ) was got from com pound (Ⅰ)by acctylation,methylation of compound (Ⅰ)with diazomethane gave methyl (13E, 15E, 17E, 22E, 24E ) -3, 12-dioxoisomalabarica-13, 15, 17, 22, 24-pentaen-26-oate (Ⅵ).