摘要盆底器官脱垂（pelvic organ prolapse,POP）又称盆腔器官膨出,是一种常见的、严重影响妇女生活质量的妇科疾病。当盆底组织退化、创伤、先天发育不良或某些疾病引起损伤、张力减低导致其支持功能减弱,使女性生殖器官和相邻脏器向下移位,即为POP。2002年美国妇女健康研究调查发现,50～79岁妇女中约40%有不同程度的POP。
1OLSEN A L,SMITH V J,BERGSTROM J O,et al.Epidemiology of surgically managed pelvic organ prolapse and urinary incontinence[J].Obstet Gynecol,1997,89(4):501-506.
4DREWES P G,YANAGISAWA H,STARCHER B,et al.Pelvic organ prolapse in fibulin-5 knockout mice:pregnancy changes in elastic fiber homeostasis in mouse vagina[J].Am J Pathol,2007,170(2):578-589.
5LIU X,ZHAO Y,PAWLYK B,et al.Failure of elastic fiber homeostasis leads to pelvic floor disorders[J].Am J Pathol,2006,168(2):519-528.
6NAKAMURA T,LOZANO P R,IKEDA Y,et al.Fibulin-5/DANCE is essential for elastogenesis in vivo[J].Nature,2002,415(6868):171-175.
7YANAGISAWA H,DAVIS E C,STARCHER B C,et al.Fibulin-5 is an elastin-binding protein essential for elastic fibre development in vivo[J].Nature,2002,415(6868):168-171.
8RITZ TIMME S,LAUMEIER I,COLLINS M J.Aspartic acid racemization:evidence for marked longevity of elastin in human skin[J].Br J Dermatol,2003,149(5):951-959.
9KERKHOF M H,HENDRIKS L,BRLMANN H A.Changes in connective tissue in patients with pelvic organ prolapse--a review of the current literature[J].Int Urogynecol J Pelvic Floor Dysfunct,2009,20(4):461-474.
10STARCHER B,PERCIVAL S.Elastin turnover in the rat uterus[J].Connect Tissue Res,1985,13(4):207-215.
3Fitzgerald MP, Mollenhauer J, Hale DS, et al. Urethral collagen morphologic characteristics among women with genuine stress incontinence [ J]. Am J Obstet Gynecol, 2000, 182(6) :1565 - 1574.
4Chen B, Wen Y, Warrington JA, et al. Menstrual phase -dependent gene expression differences in preiurethral vaginal tissue from women with stress incontinence [ J]. Am J Obstet Gynecol, 2003, 189 ( 1 ) :89 - 97.
5Chen B, WenY, Wang HB, et al. Differencesin estrogen modulation of tissue inhibitor of matrix metalloproteinase - 1 and matrix metallopmteinase - 1 expression in cultured fibroblasts from continant and incontinent women [ J ]. Mosby Year Book Inc, 2003, 189( 1 ) :59 -65.
6Yamamoto M, Aoyagi M, Tajima S, et al. Increase in elastin gene expression and protein synthesis in arterial smooth muscle cells derived from patients with moyamoya disease [ J ]. Stroke, 1997, 28 (9) : 1733 - 1738.
7Yamamoto K, Yamamoto M, Akazawa K, et al. Decrease in elastin gene expression and protein synthesis in fibro- blasts derived from cardinal ligaments of patients with prolapsus uteri[J]. Cell Biol Int, 1997, 21(9):605 -611.
8Szauter KM, Cao T, Boyd CD, et al. Lysyl oxidase in development, aging and pathologies of the skin [ J ]. Pathol Biol, 2005, 53(7) :448 -456.
9Maki JM, Sormunen R, Lippo S, et al. Lysyl oxidase is essential for normal development and function of the respiratory system and for the integrity of elastic and collagen fibers in various tissues[J]. Am J Pathol, 2005, 167(4): 927 - 936.
10Kobak W, Lu J, Hardart A,et al. Expression of lysyl oxidase and transforming growth factor beta 2 in women with severe pelvic organ prolapse [ J ]. J Reprod Med, 2005, 50 ( 11 ) :827 -831.
