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Th17／IL-23免疫轴与克罗恩病疾病活动性的临床研究 被引量：3

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摘要 目的探讨Th17细胞／IL-23免疫轴相关细胞因子与克罗恩病（CD）疾病活动性的关系。方法对本院确诊克罗恩病55例（观察组，其中缓解期13例，中度活动期31例，重度活动期11例）及10例正常肠黏膜组织作对照，采用免疫组化ABC法测定其组织中IL-17、IL-23P19、ROR-γt的蛋白表达，比较各组的表达意义。结果IL-17在正常组和缓解期组低表达，两组比较差异无统计学意义（P〉0．05），而在中度活动期组及重度活动期组表达依次增加，备组比较差异均有统计学意义（P〈0．05或P〈0．01）；IL-23P19在缓解期组、中度活动性组、重度活动期组表达依次增加，各组比较差异均有统计学意义（P〈0．05或P〈0．01）；ROR-γt在缓解期组、中度活动期组、重度活动期组表达依次增加，各组比较差异均有统计学意义（P〈0．05或P〈0．01）。结论Th17细胞／IL-23免疫轴参与了克罗恩病肠黏膜的免疫损伤，其细胞因子在肠黏膜组织表达水平的高低与疾病的严重程度有关。
作者 周明欢 李学锋 卢放根 邹益友
机构地区 湘西自治州人民医院消化科 深圳市龙岗区人民医院消化科 中南大学湘雅二医院消化科 中南大学湘雅医院消化科
出处 《中国医师杂志》 CAS 2011年第11期1539-1541,共3页 Journal of Chinese Physician
基金 基金项目：湖南省科技厅科技专项计划基金（2010FJ4085）
关键词 Crohn病/免疫学 白细胞介素23/免疫学 抗原 CD4/免疫学 T淋巴细胞亚群
分类号 R574 [医药卫生—消化系统]
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参考文献15

  • 1Leong RW, Lau JY, Sung JJ. The Epidemiology and Phenotype of Crohn's Disease in the Chinese Population. Inflamm Bowel Dis,2004,10(5 ) :646-651.
  • 2Goh K, Xiao SD. Inflammatory bowel disease : A survey of the epi- demiology in Asia. J Dig Dis,2009,10( 1 ) :1-6.
  • 3Parronehi P, Romagnani P, Annunziato F, et al. Type 1 T - help- er cell predominance and interleukin - 12 expression in the gut of patients with Crohn's disease. Am J Pathol, 1997,150(3 ):823- 832.
  • 4Ljung T, Karlen P, Schmidt D, et al. Infliximab in inflaramatory bowel disease:clinical outcome in a population based cohort from Stockholm County. Gut,2004,53 (6) : 849-853.
  • 5Weaver CT, Hatton RD, Mangan PR,et al. IL-17 family cytokines and the expandingdiversity of effector T cell lineages. Annu Rev Immunol,2007,25(1) :821-852.
  • 6Kastelein RA, Hunter CA, Cua DJ. Discovery and biology of IL-23 and IL-27 : related but functionally distinet regulators of inflamma- tion. Annu Rev Immunol,2007,25 ( 1 ) :221-242.
  • 7欧阳钦,潘国宗,温忠慧,万学红,胡仁伟,林三仁,胡品津.对炎症性肠病诊断治疗规范的建议[J].中华消化杂志,2001,21(4):236-239. 被引量：1124
  • 8中华医学会消化病学分会炎症性肠病协作组,欧阳钦,胡品津,钱家鸣,郑家驹,胡仁伟.对我国炎症性肠病诊断治疗规范的共识意见(2007年，济南)[J].中华消化杂志,2007,27(8):545-550. 被引量：1024
  • 9Best WR. Predicting the Crohn's disease activity index from the harvey-bradshaw index. Inflamm Bowel Dis, 2006, 12 ( 4 ) : 304- 310.
  • 10Kakazu T, Hara J, Matsumoto T, et al. Type 1 T - helper cell predominance in granulomas of Crohn's disease. Am J Gastroen- terol, 1999,94 ( 8 ) :2149-2155.

二级参考文献15

  • 1潘国宗 刘彤华 见:潘国宗 曹世植9. 主编.溃疡性结肠炎[A].见:潘国宗,曹世植9.,主编.现代胃肠病学.第Ⅰ版[C].北京:科学出版社,1994.1246-1247.
  • 2潘国宗 刘彤华.Crohn病[A].见:潘国宗 曹世植 主编.现代胃肠病学[C].北京:科学出版社,1994.1154.
  • 3樋渡信夫 渡边浩光 前川浩树 等.溃疡性结肠炎的诊断标准与诊断进展[J].炎症性肠疾患胃与肠,1997,32(3):271-278.
  • 4欧阳钦.炎症性肠病的诊治进展.见:孟宪镛主编.实用消化病诊疗学.第2版.上海:世界图书出版社,2006.362-84.
  • 5Ouyang Q, Tandon R, Goh KL, et al. The emergence of inflammatory bowel disease in the Asian Pacific region. Curr Opin Gastroenterol,2005: 21:408-413.
  • 6Satsangi J, Silverberg MS, Vermeire S, et al. The Montreal classification of inflammatory bowel disease: controversies, con sensus, and implications. Gut, 2006, 55:749-753.
  • 7Zheng JJ. Clinical aspects of ulcerative colitis in China's Mainland. Chin J Dig Dis, 2006, 7:71-75.
  • 8Hanauer SB, Sandborn W, Practice Parameters Committee of the American College of Gastroenterology. Management of Crohn's disease in adults. Am J Gastroenterol, 2001, 96: 635- 643.
  • 9Stange EF, Travis SP, Vermeire S, et al. European evidence based consensus on the diagnosis and management of Crohn's disease: definitions and diagnosis. Gut, 2006, 55 Suppl 1:i1- i15.
  • 10Carter MJ, Lobo AJ, Travis SP. Guidelines for the management of inflammatory bowel disease in adults. Gut, 2004, 53 Suppl 5: Ⅴ1-Ⅴ16.

共引文献2118

同被引文献27

  • 1Zhao L, Yang J, Wang HP, et al. Imbalance in the Thl7/ Treg and cytokine environment in peripheral blood of pa- tients with adenocarcinoma and squamous cell carcinoma[J]. Med Oncol, 2013, 30(1):461.
  • 2Fleet JC, DeSmet M, Johnson R, et al.Vitamin D and can- cer: a review of molecular mechanisms[J]. Biochem J, 2012, 441( 1 ) :61-76.
  • 3Greenlee H, White E, Patterson RE, et al. Supplement use among cancer survivors in the Vitamins and Lifestyle (VI- TAL) study cohort[J]. J Ahem Complement Med, 2004, 10 (4) : 660-666.
  • 4Grant WB. Does solar uhraviolet irradiation affect cancer mortality rates in China[J]. Asian Pac J Cancer Prey, 2007,8 (2) : 236-242.
  • 5Mohr SB, Garland CF,Gorham ED, et al. Could ultraviolet B irradiance and vitamin D be associated with lower inci- dence rates of lung cancer[J]. J Epidemiol community health, 2008,62( 1 ):69-74.
  • 6Ye J, Livergood RS, Peng G.The role and regulation of hu- man Thl7 cells in tumor immunity [J]. Am J Pathol, 2013, 182( 1 ) : 10-20.
  • 7Goettel A, Scott HM, 0livares-Villagomez D, et ah KSR1 protects from interleukin-10 deficiency-induced colitis in mice by suppressing T lymphocyte interferon-3, production[J]. Gastroenterology, 2011,140( 1 ) : 265-274.
  • 8Zhao L,Yang J,Wang HP. Imbalance in the Th17/Treg and cytokine environment in peripheral blood of patients with adenocarcinoma and squamous cell carcinoma[J].{H}MEDICAL ONCOLOGY,2013,(01):461.
  • 9Fleet JC,DeSmet M,Johnson R. Vitamin D and cancer:a review of molecular mechanisms[J].{H}BIOCHEMICAL JOURNAL,2012,(01):61-76.
  • 10Grant WB. Does solar ultraviolet irradiation affect cancer mortality rates in China[J].{H}Asian Pacific Journal of Cancer Prev,2007,(02):236-242.

引证文献3

二级引证文献9

中国医师杂志
2011年 第11期

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