维生素D与冠状动脉粥样硬化性心脏病

Vitamin D and Coronary Atherosclerotic Heart Disease

维生素D是机体内维持钙磷平衡的重要有机物质。近年来,许多研究发现机体内维生素D水平的失衡与冠状动脉粥样硬化性心脏病(简称冠心病)发病密切相关。维生素D失衡可能会导致冠状动脉血管炎症、钙化,心肌肥厚,血管平滑肌细胞增殖,并且终末期的肾病患者易罹患冠心病。维生素D水平的失衡可能是冠心病的危险因素,这为干预冠心病高危人群、探索冠心病临床辅助治疗开辟了新的方向。

Vitamin D is an important organic substance which maintains the balance of calcium and phosphorus in our bodies.In recent years,many clinical studies found that the imbalance of vitamin D′s levels was closely related to coronary atherosclerotic heart disease（CHD for short）.The imbalance of vitamin D′s levels may lead to coronary vascular inflammation,calcification,cardiac hypertrophy,and vascular smooth muscle cell proliferation.Also,end-stage kidney disease patients could be CHD susceptible.The imbalance of vitamin D′s levels may be risk factors for CHD,which opens up a new direction for intervening the CHD high-risk groups and exploring the adjuvant treatment.