摘要
血管紧张素Ⅱ(AngⅡ)是肾素-血管紧张素系统(RAS)中的主要效应分子,AngⅡ除了调节机体血压、维持水电解质平衡外,还可以上调多种致炎性因子的表达,在促进肺纤维化、肺实质细胞凋亡、炎性反应、肺水肿等方面发挥着一定作用,与ALI发生、发展及预后关系密切。通过深入研究局部肺组织中AngⅡ及其相关受体信号通路在ALI中的致病机制和作用,可能为ALI临床防治提供新的思路和方向。
Angiotensin Ⅱ（Ang Ⅱ）is the primary effector molecule of renin angiotensin system（RAS）.In addition to regulating the body′s blood pressure and maintain water electrolyte balance,AngⅡ can also up-regulate the expression of multiple inflammation factors,which plays an important role in promoting pulmonary fibrosis,lung parenchyma cell apoptosis,inflammation and pulmonary edema,closely related to acute lung injury（ALI）in its onset,development and prognosis.In-depth studying the pathogenic mechanism and function of AngⅡ in local lung tissue and its signaling pathways with related receptors in ALI may provide new ideas and direction for clinical prevention and treatment of ALI.
出处
《医学综述》
2011年第23期3529-3532,共4页
Medical Recapitulate
基金
广西自然科学基金(2010GXNSFA013253)
