期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Th17细胞与银屑病 被引量：1

Th17 and Psoriasis
下载PDF
导出
摘要 Th17细胞是近年来发现的不同于Th1、Th2和调节性T细胞的一类特殊的新型CD4+T细胞亚群,通过分泌以白细胞介素17为主的一系列效应细胞因子参与多种慢性炎性反应和自身免疫性疾病。Th17细胞及相关因子在银屑病的免疫发病机制中起着非常重要的调节作用。现从Th17相关细胞因子的角度出发来分析Th17分化调控的特点及其在介导银屑病发生、发展过程中的重要作用。 Th17 is a newly discovered novel subset of CD4 ＋ T effect cells different from Th1,Th2,and Tregs.It plays an important role in multiple chronic inflammatory reactions and autoimmune diseases by the secretion of a series of effect cytokines represented by interleukin 17.Th17 and related factors play a very important regulatory part in the immune pathogenesis of psoriasis.Here is to analyse the characteristics of differentiation regulation of Th17 and the vital function in the occurrence and development of psoriasis from the Th17 related cell factors.
作者 康恺 周晓鸿
机构地区 昆明医学院第二附属医院皮肤科
出处 《医学综述》 2011年第23期3536-3540,共5页 Medical Recapitulate
基金 云南省应用基础研究面上项目(2009CD174)
关键词 TH17 细胞因子 银屑病 白细胞介素17 白细胞介素23 Th17 Cytokines Psoriasis Interleukin 17 Interleukin 23
分类号 R755 [医药卫生—皮肤病学与性病学]
  • 相关文献

参考文献42

  • 1Cua DJ,Sherlock J,Chen Y,et al.Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain[J].Nature,2003,421(6924):744-748.
  • 2Langrish CL,Chen Y,Blumenschein WM,et al.IL-23 drives a pathogenic T cell population that induces autoimmune inflammation[J].J Exp Med,2005,201(2):233-240.
  • 3Veldhoen M,Hocking RJ,Atkins CJ,et al.TGF-β in the context of an inflammatory cytokin milieu supports De Novo differentiation of IL-17-producing T cells[J].Immunity,2006,24(2):179-189.
  • 4Bettelli E,Carrier Y,Gao W,et al.Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells[J].Nature,2006,441(7090):235-238.
  • 5Yang XO,Panopoulos AD,Nurieva R,et al.STAT3 regulates cytokine-mediated generation of inflammatory helper T cells[J].J Biol Chem,2007,282(13):9358-9363.
  • 6Korn T,Bettelli E,Gao W,et al.IL-21 initiates an alternative pathway to induce proinflammatory Th17 cell[J].Nature,2007,448(7152):484-487.
  • 7Wei L,Laurence A,Elias KM,et al.IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner[J].J Biol Chem,2007,282(48):34605-34610.
  • 8Nurieva R,Yang XO,Martinez G,et al.Essential autocrine regulation by IL-21 in the generation of inflammatory T cells[J].Nature,2007,448(7152):480-483.
  • 9Nurieva RI,Chung Y,Hwang D,et al.Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1,2,or 17 cell lineages[J].Immunity,2008,29(1):138-149.
  • 10Suto A,Kashiwakuma D,Kagami S,et al.Development and characterization of IL-21-producing CD4+T cells[J].J Exp Med,2008,205(6):1369-1379.

二级参考文献20

  • 1Castellino F,Germain RN.Cooperation between CD4^+ and CD8^+ T cells:when,where,and how.Annu Rev Immunol 2006;24(1):519-540.
  • 2Park H,Li Z,Yang XO,et al.A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17.Nat Immunol 2005;6(11):1133-1141.
  • 3Weaver CT,Harrington LE,Mangan PR,et al.Th17:an effector CD4 T cell lineage with regulatory T cell ties.Immunity 2006;24(6):677-680.
  • 4Mangan PR,Harrington LE,O'Quinn DB,et al.Transforming growth factor-beta induces development of the T(H) 17 lineage.Nature 2006;441(7090):231-234.
  • 5Veldhoen M,Hocking RJ,At kins CJ,et al.TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells.Immunity 2006;24(2):179-189.
  • 6Ivanov II,McKenzie BS,Zhou L,et al.The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17 + T helper cells.Cell 2006;126(6):1121-1133.
  • 7Harris TJ,Grosso JF,Yen HR,et al.An in vivo requirement for STAT3 signaling in T(H)17 development and T(H)17-dependent autoimmunity.J Immunol 2007;179(7):4313-4317.
  • 8Chen Z,Laurence A,Kanno Y,et al.Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells.Proc Natl Acad Sci USA 2006;103(21):8137-8141.
  • 9Laurence A,Tato CM,Davidson TS,et al.Interleukin22 signaling via STAT5 constrains T helper 17 cell generation.Immunity 2007;26(3):371-375.
  • 10Lim HW,Lee J,Hillsamer P,et al.Human Th17 cells share major trafficking receptors with both polarized effector T cells and FOXP3(+) regulatory T cells.J Immunol 2008;180(1):122-129.

共引文献1

同被引文献1

引证文献1

二级引证文献1

医学综述
2011年 第23期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部