内脂素的生理作用及其与肥胖的关系研究进展

Research Advancement in Visfatin′s Physiological Role and its Relationship with Obesity

脂肪组织不仅是一个简单的能量储存器官,更是具有重要内分泌及免疫功能的组织器官。脂肪组织来源的细胞因子可通过参与慢性炎性反应而参与到肥胖、胰岛素抵抗、β细胞功能障碍、内皮细胞功能障碍以及动脉粥样硬化等的形成过程。内脂素作为新近发现的一种脂肪细胞因子,因其与糖脂代谢、胰岛素抵抗、炎性反应以及与肥胖、冠心病等疾病的关系而受到越来越多的关注。

At present,most of studies demonstrate that adipose tissue is not only an energe storage organ,but also an organ with vital endocrine and immune function in human body.The adipocytes from the adipose tissue are involved in the formation of obesity,insulin resistance,β cell dysfuction,endothelial cell dysfunction and atherosclerosis through the chronic inflammatory response.Visfatin,as a newly discovered adipocytokine,is drawing more and more attention because of its relations with glucose and lipid metabolism,insulin resistance,inflammatory response and diseases such as obesity and coronary heart disease.