不同厂家黄连上清片特征指纹图谱比较

Comparison Research of Characteristic Fingerprints of Huanglian Shangqing Tablets from Different Manufacturers

目的:研究不同厂家和不同批次黄连上清片指纹图谱及色谱峰面积的差异。方法:采用高效液相色谱法,比较不同厂家和同一厂家不同批次黄连上清片特征指纹图谱的差异,并通过相似度软件分析其相似性。结果:不同厂家生产的黄连上清片在所含色谱峰的数目和峰面积上存在很大差异;同一厂家不同批号黄连上清片所含色谱峰的数目基本相同,含量虽然存在一定的差异,但相对不同厂家的差异较小。结论:不同厂家的黄连上清片指纹图谱变异范围差异较明显,同一厂家的产品质量基本稳定在一定水平内。

Objective： To study the difference in fingerprints and chromatographic peak area of different batches of Huanglian Shangqing pills from different manufacturers.Method： HPLC was used to compare the difference of characteristics fingerprints of different batches of Huanglian Shangqing tablets from different or same manufacturers.The similarity was analyzed with the similarity evaluation software.Result： There were big differences in the number of peaks and peak area of Huanglian Shangqing tablets from different manufacturers.The number of peaks of different batches of Huanglian Shangqing tablets from the same manufactures were almost similar,while the contents of them existed a certain difference.Relative to the different manufacturers,the difference of the content of different batches of Huanglian shangqing tablets was smaller among the same manufacturers.Conclusion： The variation of fingerprint of Huanglian Shangqing tablets is relatively obvious among different manufacturers,but the quality of Huanglian Shangqing tablets from the same manufactures is basically stable at a certain level.