济民风湿王抗炎、镇痛和对急性软组织损伤作用

Therapeutic Effect of Jiming Fengshiwang on Anti-inflammation, Analgesic and Acute Soft Tissue Injury

目的:考察济民风湿王抗炎、镇痛和对急性软组织损伤作用。方法:受试药外用,连续给药7 d,济民风湿王给药剂量小鼠、大鼠分别为10.0,5.0,2.5 mL.kg-1。通过小鼠耳肿胀法、大鼠足肿法、对佐剂性关节炎的影响观察其抗炎作用;采用热板法和光热致痛法观察其镇痛作用;自由落体组织损伤模型观察其抗急性软组织损伤作用。结果:济民风湿王能明显减轻巴豆油引起的小鼠耳肿,明显减轻角叉菜胶所致大鼠足肿,明显抑制佐剂性关节炎的原发和继发性炎症反应(P<0.01,P<0.05);显著提高热板试验中小鼠的痛阈值、光热瘤阈值(P<0.01,P<0.05);明显降低损伤大鼠的表观损伤积分,改善损伤组织的病理学形态(P<0.01,P<0.05)。结论:济民风湿王具有抗炎镇痛,抗急性软组织损伤的作用。

Objective：To observe the fluence of Jiming Fengshiwang on anti-inflammation,analgesic and cute soft tissue injury disease.Method： Jiming Fengshiwang were given 10.0,5.0,2.5 mL·kg-1 daily by external administration for 7 days.The anti-nflammatory effect was investigated by methods of ear swelling in mice,hind paw edema and adjuvant-induced arthritis in rats.The analgesic effect was observed with hot-plate test in mice and tail-contracting test with light-hot stimulus in mice.The effects of Jiming Fengshiwang on soft tissue injury in mice was tested by damages caused by freely falling mass damages models.Results： Jiming Fengshiwang could obviously inhibit ear swelling in mice induced by croton oil,hind paw edema in rats induced by carrageenan and the original and secondary inflammatory changes of adjuvant-induced arthritis in rats,could otviously prolong the pain threshold of temperature stimuli in mice,and resisting the acute soft tissue injury.Conclusion： Jiming Fengshiwang has anti-inflammation,analgesic,treating soft tissue injury effects.