基于1307首方剂的平性药病证配伍用药规律研究

Study on Compatibility Regularityof Neutral-Nature Chinese Medicine for Treatment of Diseases and Syndromes Based on 1 307 Prescriptions

目的:通过分析1 307首方剂的药性组方规律,探讨平性药临床用药规律。方法:从国家级规划教材《方剂学》及《中华人民共和国药典》(以下简称《药典》)中筛选1 307首方剂,并以《药典》记的载药性为判定依据,将获得的数据录入"中药方剂药性数据分析系统",分析了寒热平药性与组方角色的关系、寒热平药性组方角色与主治病证的关系等;采用SPSS 13.0统计软件,对平性药配伍与不同病证之间的相关性进行两两相关分析及二分类非条件logistic回归分析。结果:平性药作使药者为寒、热药的3.9倍,平性药作君、臣药的方剂,以治疗气虚证者最多,其次是瘀血证和痰湿证;平性药在寒证、热证、不寒不热证、寒热错杂证的总体应用频率分别为22%,18%,25%,18%,在虚证、实证、虚实夹杂证中的总体应用频率分别为27%,17%,25%;在气虚证、血虚证、寒证、不寒不热证、虚证中,平性药的应用频次分别是寒性药+热性药的1.5,1.4,1.4,1.6,1.2倍。结论:平性药在组方配伍时最常作使药;平性药多用于虚证和虚实夹杂证,是气虚证、血虚证、寒证、不寒不热证、虚证等病证的常用药,比寒热药物更宜于临床配伍应用。

Objective： By analyzing the compatibility regularity of Chinese medicine in one thousand three hundred and seven prescriptions,to discuss the application regularity of the herbs with neutral nature.Method： One thousand three hundred and seven prescriptions were screened from Herbal Prescription Science and 〈Pharmacopoeia of the People＇s Republic of China〉,and the herbal nature was determined according to the Pharmacopoeia,the data were inputted into the database software,Data Analysis System of Traditional Chinese Medicine Herbal Prescription to analyze the relationship between herbal nature and prescription,and the relationship between prescription and syndromes.The paired correlation analysis and two categories of non-conditional logistic regression analysis were carried on by SPSS 13.0 statistic software to analyze the relativity between compatibility of Chinese medicines with neutral nature and different syndromes.Result： The number of the Chinese medicines with neutral nature as a guide drug was 3.9 times more than the Chinese medicines with cold and heat nature.The Chinese medicines with neutral nature as a monarch drug and a minister drug were firstly used in deficiency syndrome,secondly used in blood stasis syndrome and phlegm-dampness syndrome.The total application frequencies of the Chinese medicines with neutral nature which were used in cold syndrome,heat syndrome,the syndrome without obvious cold and heat,and the syndrome of intermingled cold and heat,were 22%,18%,25%,and 18%,respectively;the frequencies in deficiency syndrome,excess syndrome,and the syndrome of intermingled deficiency and excess,were 27%,17%,25%,respectively;the frequencies in qi deficiency syndrome,blood deficiency syndrome,cold syndrome,syndrome without obvious cold and heat,and deficiency syndrome,were 1.5,1.4,1.6,1.2 times,respectively,more than the herbs with cold and heat nature.Conclusion： In terms of compatibility regularity,the Chinese medicines with neutral nature are most frequently used as guide drug;in terms of the diseases and syndromes,they are commonly used in deficiency syndrome,and the syndrome of intermingled deficiency and excess.The Chinese medicines with neutral nature are commonly used herbs in Qi deficiency syndrome,blood deficiency syndrome,cold syndrome,the syndrome without obvious cold and heat,and deficiency syndrome,and more appropriate for compatible application than the Chinese medicineswith cold and heat nature.