利用文本挖掘技术探索中西药治疗慢性乙型肝炎的用药规律

Regularity of Chinese and Western Medicine Application for Chronic Hepatitis B with Text Mining Technique

目的:利用文本挖掘探索中西药治疗慢性乙型肝炎的核心药物及其组合关系。方法:采集治疗慢性乙型肝炎的相关文献,建立Access数据库,运用SQL对数据进行处理,结合人工降噪后,挖掘中西药系统治疗慢性乙型肝炎的用药规律。结果:丹参、黄芪、柴胡、虎杖、甘草、苦参、天冬、茵陈、栀子是中医复方配伍治疗乙肝的核心药物;干扰素和丹参注射液分别是治疗乙肝的最常用西药和中成药;干扰素、拉米夫定、胸腺肽、谷胱甘肽、维生素C等常与丹参注射液联合使用,黄芪注射液、益肝灵、护肝片、肝苏颗粒等常与拉米夫定联合使用。结论:文本挖掘获得的中西药治疗慢性乙型肝炎的用药规律不仅反映了临床用药实际,而且拓展了临床用药的范畴与思路。

Objective： To explore primary Chinese and western medicines treating chronic hepatitis B and their combination regularity with text mining technique.Method： Literatures on Chinese and western medicines treating chronic hepatitis B were collected from Chinese biomedical literature database（CBM） and access database was established.Above data were processed by SQL,meanwhile,data noise was removed with artificial means.And then,primary Chinese and western medicines treating chronic hepatitis B and their combination regularity were received by text mining technique.Result： Chinese herbs,such as salvia,astragalus,bupleurum,polygonum,licorice,matrine,aspartame,capillaries and gardenia,were main components of Chinese herb compound treating chronic hepatitis B.Danshen injection and interferon were the most commonly used Chinese patent medicine and western medicine for chronic hepatitis B.Some western medicine,for example,Interferon,lamivudine,thymosin,glutathione and vitamin C were often used in combination with Danshen injection.In addition,lamivudine was applied with astragalus injection,yiganling,hugan slices or gansu particles.Conclusion： Primary application of Chinese and western medicines treating chronic hepatitis B and their combination regularity not only reflect clinical practical state,but also expanded the scopes and thingking of clinical application of Chinese and western medicine.