了哥王的化学成分和药理作用研究进展

Reviews on Chemical Constituents and Pharmacological Action of Wikstroemia indica

通过查阅、整理国内外有关了哥王的文献资料,对其化学成分和药理毒副作用进行归纳总结。化学成分主要包括香豆素类、黄酮类和木脂素类等,且多具生理活性;药理作用主要有抑菌、抗病毒、抗炎镇痛、抗肿瘤作用等;了哥王作为一种有毒中药,其毒副作用方面也应引起足够重视,服用剂量不宜过大,孕妇忌用。近年来报道证实了哥王有显著的抗肿瘤活性,使该药成为研究热点。建议深入系统地开展其化学成分研究。

By resourcing and sorting the references of Wikstroemia indica at home and abroad,it has been summarized the chemical constituents and the pharmacological action of Wikstroemia indica.It has many chemical constituents with biological activities,such as coumarin,flavone and lignanoid.Beside the antitumor activity,which has become one of the hot sports in resent academic research,it has antibacterial,antiviral,anti-inflammatory and analgesic effects etc.As one of the toxic herbs,more attention should be paid to its toxic-side effects to ensure the safety and rationality in clinic and to provide a basis for its further development and application.