20(S)-原人参二醇的药理作用研究进展

Research Progress on Pharmacological Activity of 20(S)-protopanaxadiol

目的:对20(S)-原人参二醇的药理作用方面的研究进行文献整理和分析。方法:查阅中国知网,万方数据,维普,Springer,Pubmed,Ovid等数据库中近15年来国内外有关中药活性化合物20(S)-原人参二醇的近30篇文献资料,对其药理活性按研究的热门程度进行统计概括。结果:20(S)-原人参二醇具有抗癌、抗抑郁、激活氯离子通道和抑制钠离子通道去极化的作用、抑制人胚肾HEK-293细胞和幽门螺旋杆菌生长等诸多药理活性。结论:首次对20(S)-原人参二醇的药理活性进行较为全面的整理,为医药学科研人员今后开展有关20(S)-原人参二醇的药理研究提供参考和借鉴,今后应加强其药理作用机制及毒性的研究,为开发新药打下基础。

Objective：To review and analyze the research papers of 20（S）-protopanaxadiol pharmacological activity.Method：References in CNKI,Wan Fang VIP,Springer,Pubmed,Ovid and other databases were accessed for 20（S）-protopanaxadiol,an active compound of troditional Chinese medicine.Some thirty papers in the past 15 years home and abroad were summarized statistically for its pharmacological activity by popularity.Result：20（S）-protopanaxadiol has anti-cancer,anti-depressant actions.It also shows actions of activating chloride ion channel,inhibiting the depolarization of activated sodium Channel,and inhibiting the growth of human embryonic kidney HEK-293 cells and Helicobacter pylori and many other pharmacological activity.Conclusion： The 20（S）-protopanaxadiol′s pharmacological activities are comprehensively summarized,which may give a reference for the medical researchers to carry out the 20（S）-protopanaxadiol pharmacological research in the future.For new drug development,studies on pharmacological mechanisms and toxicity should be carried out in the futnre.