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抗晚期乳腺癌新药——甲磺酸艾日布林 被引量:1

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摘要 2010年11月15日,美国FDA批准了日本卫材公司研发用于治疗转移性乳腺癌的新药甲磺酸艾日布林(efibulinmesylate,商品名Halaven)上市,本品是一种微管抑制剂,其抗癌作用机制与紫杉醇基本相同。其分子式为C40H59NO11·CH4O3S,分子量为826.0(游离碱为729.9)。
出处 《中国药学杂志》 CAS CSCD 北大核心 2011年第23期1855-1856,共2页 Chinese Pharmaceutical Journal
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  • 1FDA. Label approved on 11/15/2010 for HALAVEN, NDA no. 201532 [ EB/OL]. http://www, accessdata.fda, gov/drugsatfda docs/label/2010/2015321bl, pdf.
  • 2Twelves C, Cortes J, Vahdat L T, et al. Please III trials of eribulin mesylate (E7389) in extensively pretreated patients with locally recurrent or metastatic breast cancer [ J]. Clin Breast Cancer, 2010,10(2) :160-163.
  • 3JENNIFER A S, LESLIE W, OLGA AZARENKO, et al. Eribulin Binds at Microtubule Ends to a Single Site on Tubulin to Suppress Dynamic Instability[ J]. Biochem, 2010, 49(6) : 1331 - 1337.
  • 4JAVIER C, ALBERTO J M, STEFAN G. Eribulin rnesylate, a novel microtubule inhibitor in the treatment of breast cancer [ J ]. Cancer Treat Rev, 2011, 22(10) :1-12.

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  • 2Parkin DM , Bray F , Fcrlay J, et aL Global cancer statistics, 2002 [J]. CA Cancer J Clin,2005,55(2) :74-108.
  • 3Yang L , Parkin DM , Ferlay J, et al. Estimates of cancer incidence in China for 2000 and projections for 2005 [ J ]. Cancer Epidemiol Bio- markers Prey,2005 , 14( 1 ) :243-250.
  • 4Jcmal A, Siegel R, Ward E, et al. Cancer statistics, 2008 [ J]. CA Cancer J Clin,2008,58(2) :71-96.
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  • 6Cortes J, OShaughnessy .I, Loesch D ,et al. Eribulin monotherapy ver- sus treatment of physician's choice in patients with metastatie breast cancer (EMBRACE) : A phase 3 open -label randomised study[ J]. Lancet,2011,377(9769) : 914-923.
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