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IGF-Ⅱ/IGF-ⅠR相关信号通路与肝细胞癌靶向治疗 被引量：1

Insulin-like growth factor (IGF)-Ⅱ/IGF-ⅠR related signaling pathway and molecular targeted therapy for hepatocellular carcinoma
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摘要 胰岛素样生长因子(insulin-like growth factor,IGF)-Ⅱ/IGFⅡ-ⅠR相关信号通路与肝细胞癌(hepatocellular carcinoma,HCC)发生发展密切相关.IGF-Ⅱ活化可经IGF-ⅠR传递促有丝分裂信号,增加HCC变可能.近来研究显示靶向IGF-Ⅱ或IGF-ⅠR可明显抑制HCC细胞增殖.本文就IGF-Ⅱ和IGF-ⅠR信号通路在肝细胞癌变、转化过程中的作用及作为HCC基因治疗靶目标的研究进展进行了评述. The insulin-like growth factor （IGF）-Ⅱ/IGF-Ⅰreceptor （IGF-ⅠR） related signaling pathway is associated with the development and progression of hepatocellular carcinoma （HCC）. Hepatic IGF-Ⅱactivation can deliver a mitogenic signal to IGF-ⅠR to increase the tumorigenic potential of liver cells. Recently, a considerable amount of evidence suggests that targeted inhibition of IGF-Ⅱ and IGF-ⅠR could inhibit the proliferation of hepatoma cells. In this review, we summarize the interaction of IGF-Ⅱ and IGF-ⅠR in hepatocarcinogenesis and evaluate their potential use in molecular targeted therapy for hepatocellular carcinoma.
作者 姚登福 姚敏 蔚丹丹
机构地区 南通大学附属医院临床医学研究中心
出处 《世界华人消化杂志》 CAS 北大核心 2011年第29期3009-3014,共6页 World Chinese Journal of Digestology
基金 江苏省自然科学基金资助项目 No.BK2008187~~
关键词 胰岛素样生长因子-Ⅱ 胰岛素样生长因子-Ⅰ受体 分子靶向 肝细胞癌 Insulin-like growth factor-Ⅱ Insulin-like growth factor-Ⅰ receptor Targeted therapy Hepatocellular carcinoma
分类号 R735.7 [医药卫生—肿瘤]
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世界华人消化杂志
2011年 第29期

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