天钩降压胶囊对麻醉Beagle犬血压及血流动力学的影响

Effects of Tiangou Jiangya capsule on hypertension and hemodynamics in anaesthetized dogs

目的:评价天钩降压胶囊对麻醉Beagle犬血压及血流动力学的影响。方法:天钩降压胶囊设置1.6,3.2,6.4 g.kg-13个剂量组(按生药计),以卡托普利为阳性对照药,0.5%CMC-Na为阴性对照药,十二指肠给药,观察麻醉犬血压及血流动力学的变化。结果:天钩降压胶囊中剂量组给药30 min后麻醉犬收缩压(SAP)明显降低,高剂量组给药后15 min SAP,舒张压(DAP)即明显降低,作用维持至给药后90 min。给予天钩降压胶囊高剂量能明显降低心脏做功(LVW)和总外周阻力(TPR)。天钩降压胶囊对其他血流动力学指标及心肌耗氧量无明显影响。结论:天钩降压胶囊具有明显降压作用,作用与降低总外周阻力有关,降压同时减少心脏做功,为进一步阐明天钩降压胶囊降血压机制提供参考。

Objective： To evaluate the effects of Tiangou Jiangya capsule on blood pressure and hemodynamics in anesthetized Beagle dogs. Method： Anesthetized dogs were divided into five groups： Tiangou Jiangya capsule 3-dose groups as 1.6, 3.2, 6.4 g·kg-1, positive control group was giving captopril, negative control was giving 0.5% CMC-Na, duodenal administration. The blood pressure and hemodynamic changes were observed. Result： The systolic blood pressure of middle-dose Tiangou Jiangya capsule group was significantly reduced at 30 min after administration. The systolic blood pressure（SAP） and diastolic blood pressure （DAP） of high-dose group of Tiangou Jiangya capsule was significantly reduced at 15 min to 90 min after administration. High-dose Tiangou Jiangya capsule can also significantly reduce cardiac work （LVW） and total peripheral resistance（TPR）. Tiangou Jiangya capsule had no significant effect on the other hemodynamic parameters and myocardial oxygen consumption. Conclusion： Tiangou Jiangya capsule has a significant effect on reducing blood pressure, which is related to the reducing total peripheral resistance and reducing cardiac work. The result can provide a reference to further clarify the Tiangou Jiangya capsule mechanism on reducing blood pressure.