冠心病患者血清胱抑素C水平及其影响因素分析

Distribution and Influencing Factors of Serum Cystatin C in Patients with Coronary Heart Disease

目的探讨冠状动脉粥样硬化性心脏病(冠心病)患者血清胱抑素C水平及冠心病危险因素对其的影响。方法分析经冠状动脉造影检查确诊为冠心病的384例患者临床资料,应用免疫比浊法检测血清胱抑素C浓度,从冠心病病情、冠状动脉病变支数等方面研究血清胱抑素C水平在冠心病患者间的分布特征;通过单因素、多因素分析研究相关危险因素对其的影响。结果随着冠状动脉病变支数增加,血清胱抑素C水平升高。冠心病患者血清胱抑素C水平随着年龄增高有升高趋势。性别、高血压、糖尿病、血脂异常、吸烟史、家族史等危险因素对冠心病患者血清胱抑素C水平无影响。多因素分析显示,年龄是影响冠心病患者血清胱抑素C水平的主要因素。结论在冠心病人群中血清胱抑素C水平主要受年龄等危险因素的影响。冠心病患者血清胱抑素C水平在一定程度上反映了冠状动脉病变的严重程度,并且可能与冠心病的病情有关,在冠心病临床治疗中是一个不容忽视的因素。

Aim To study the distribution of serum Cystatin C and analyze its associated influence factors in patients with coronary heart disease. Methods 384 patients with coronary heart disease who underwent coronary angiography were selected in the study.The concentration of serum Cystatin C was measured by immunoturbidimetry.From the pathogenetic condition of coronary heart disease,the number of diseased vessels,we study the distribution of serum Cystatin C and the impact of their risk factors in patients with coronary heart disease. Results With increase of serum levels of Cystatin C,the pathogenetic condition in patients with coronary heart disease became more serious,the number of diseased vessels increased.Likewise,with the increase of the age,levels of serum Cystatin C in patients had the same trend.Sex,hypertension,diabetes,dyslipidemia,smoking history,family history of coronary heart disease such as these risk factors were not correlated with levels of serum Cystatin C.Multivariate analysis demonstrates that age is the main factor which influences level of serum Cystatin C in patients with coronary heart disease. Conclusions Levels of serum Cystatin C is mainly affected by age and other factors,reflects the pathological changes of coronary artery and may be related to the pathogenetic condition of coronary heart disease.Therefore,it is an important factor that can not be ignored in clinical therapy of coronary heart disease.