摘要
过氧化物酶体增殖物激活受体(PPARs)是配体激活的核转录因子,属细胞核激素受体超家族成员,有PPAR-α、γ和β/8三种亚型。近年研究显示PPAR-γ在维持肠道免疫平衡、抗炎、抗肿瘤等方面发挥重要作用。溃疡性结肠炎(UC)患者存在不同程度的PPAR-γ表达障碍。本文就PPAR-γ及其配体在UC结肠炎症和结肠炎癌变中的研究进展作一综述。
Peroxisome proliferator-activated receptors （PPARs） are ligand-activated transcription factors belonging to a superfamily of nuclear hormone receptors and have a subfamily with three different isoforms： PPAR-α, PPARγ and PPAR-β/δ. Recent studies have shown that PPAR-γ plays an important role in keeping intestinal immune balance, and may exert both anti-inflammatory and antineoplastic effects. PPAR-γexpression is impaired in varying degrees in patients with ulcerative colitis （UC）. The progress in study on PPAR-γ, and its ligands in UC and colitis-associated cancer were briefly reviewed in this article.
出处
《胃肠病学》
2011年第11期682-685,共4页
Chinese Journal of Gastroenterology
