糖尿病黄斑水肿分级及其多焦视网膜电图异常改变的研究

Study of diabetic macular edema classification and multifocal electroretinogram abnormal changes

目的:探讨糖尿病黄斑水肿(DME)分级及其多焦视网膜电图P1波异常改变。方法:糖尿病眼OCT扫描后进行DME分级,后行多焦视网膜电图(mfERG)检测,分析一阶反应P1波振幅密度和潜伏期随DME进展的变化关系。结果:DME早期已有P1波振幅密度的降低(P<0.05),随后出现潜伏期延长(P<0.05)。结论:随DME进展P1波振幅密度降低和潜伏期延长,且振幅密度的改变更敏感。

Purpose：The aim of this prospective study was to investigate the abnormal changes in multifocal electroretinogram P1-wave using different diabetic macula edema（DME） scales.Methods：Diabetic eyes were divided into different DME scales after OCT scanning and the multifocal electroretinogram（mfERG） examinations were carried out subsequently.The relationship between the changes in the first-order kernel of mfERG P 1-wave latency period and response density and the diabetic macular edema scores was estimated.Results：The amplitude density showed decline firstly（P0.05）;the latency period expressed extension subsequently（P0.05）.Conclusions：With the progress of DME,the PI-wave amplitude density showed drecreasing and latency period became extension,and the changing of amplitude density represents more sensitively.