孟鲁司特钠治疗婴幼儿非特应性喘息症的疗效分析

Clinical observation of montelukast sodium for treatment of wheezing infants of non-specific symptoms

目的:观察孟鲁司特钠预防婴幼儿非特应性喘息症反复发作的临床效果。方法:80例婴幼儿非特应性喘息症[嗜酸细胞比例<0.04,血清总免疫球蛋白E(IgE)浓度为正常范围]患儿随机分为两组,对照组(40例)和治疗组(40例)。期间全部病例按照常规治疗。治疗组在常规治疗基础上加服孟鲁司特钠颗粒,每晚一次,共4个月。随访1年。测定血液嗜酸细胞比例和血清总IgE浓度,观察喘息反复发作情况。结果:液嗜酸细胞比例和血清总IgE浓度统计学差异(P>0.05),治疗组1年来反复喘息发作人数和总平均发作次数均显著低于对照组(P<0.05)。结论:采用孟鲁司特钠预防婴幼儿非特应性喘息可以有效改善患儿的症状和体征,减少喘息的发作次数。

AIM：To observe the prevention of montelukast sodium on wheezing infants of non-specific symptoms.METHODS： A total of 80 infants（Eosinophil0.04,the serum total IgE was normal） were randomly divided into two groups： the treatment group（40 patients） and control group（40 patients）.The patients in montelukast sodium treated were taken 4 mg once daily by routine complex treatment for 4 months.The two groups were followed up for 1 year.The serum total IgE and eosinophil of all patients were determined,the recurrent wheezing was observed.RESULTS：The serum total IgE and eosinophil were same in both groups（P0.05）,there were significant decrements in wheezing infants in 1 year（P0.05）.CONCLUSION： Oral administration montelukast sodium is effective,and it can reduce course of the illness and prevent recurrent wheezing in infants.