摘要
目的 探讨大剂量肉毒毒素治疗腋部多汗症的长期疗效和重复治疗的疗效.方法 92例患者随机分为两组:小剂量组为每侧腋部皮内注射生理盐水稀释的A型肉毒毒素50U;大剂量组为每侧腋部皮内注射生理盐水稀释的A型肉毒毒素200U;随访3~29个月,观察两组并发症,并建立两组等级资料,经χ2 检验,评价两组患者疗效差异.结果 两组疗效进行对照分析,经过统计学处理分析,认为对于腋部多汗症的患者,小剂量与大剂量的BTXA治疗方法的疗效间隔时间,差异有统计学意义.结论 大剂量A型肉毒毒素能够显著延长腋部多汗症复发间隔时间.
Objective Evaluate the long-term effectiveness of "high-dose" botulinum toxin therapy in axillary hyperhidrosis, the response to repeated treatment, and the possible side effects. Methods Totally 92 patients with axillary hyperhidrosis were randomly divided into two groups. One group were injected with lowdose botulinum toxin A (BTX-A) , 50 U was injected per axilla. Another group were injected with high-dose BTX-A. A total dose of 200 U of BTX-A was used per axilla. Patients were followed up for periods up to 29 months. To investigate the effect of two methods, we analyzed two ranked data by rank sum test and X2 test to judge the disparities of the therapeutic effect. Results The results showed that the relapse-free interval of two groups with axillary hyperhidrosis was significant difference through the statistical analysis. Conclusion Highdose BTX-A treatment is capable of prolonging the antihidrotic effect of intracutaneous.
出处
《中国美容整形外科杂志》
CAS
2011年第12期740-742,共3页
Chinese Journal of Aesthetic and Plastic Surgery
关键词
腋部多汗症
A型肉毒毒素
大剂量
局部注射
Axillary hyperhidrosis
Botulinum toxin A
High-dose
Local injection