奥扎格雷钠联合用药治疗老年急性脑梗死效果及安全性评价

Effects and safety of sodium ozagrel combined with cinepazide on senile people with acute cerebral infarction

目的评价奥扎格雷钠联合桂哌齐特治疗老年人急性脑梗死的效果及安全性。方法将平均85.1岁的急性脑梗死患者82例随机分为治疗组(39例)和对照组(43例)。两组均予常规治疗,在此基础上,治疗组予奥扎格雷钠注射液联合桂哌齐特注射液静脉滴注,对照组予桂哌齐特注射液联合川芎嗪注射液静脉滴注;两组疗程均为14 d,观察两组治疗前后临床疗效(神经功能缺损程度改变)。结果治疗组总有效率为92.3%,对照组为76.7%,两组比较差异有统计学意义(P<0.05)。结论奥扎格雷钠联合桂哌齐特治疗老年人急性脑梗死安全、有效。

Objective To evaluate the effects and safety of sodium ozagrel combined with cinepazide on senile people with acute cerebral infarction.Methods Eighty two patients（the average age was 85.1）with acute cerebral infarction were randomly divided into treatment group（39 cases）and control group（43 cases）.Based on the routine treatment,the treatment group received the intravenous drip of sodium ozagrel combined with cinepazide,and the control group received the intravenous drip of cinepazide combined with ligustrazine.Both groups received the treatment for 14 d.The curative effects before and after the treatment were observed（the changes of neurologic impairment degree）.Results The total effective rate of the treatment group was 92.3%,and that of the control group was 76.7%.And there were significant differences of the total effective rate between the two groups（P0.05）.Conclusion The treatment of sodium ozagrel combined with cinepazide on senile people with acute cerebral infarction is effective and safe.