生长激素运动筛查和激发试验对儿童GH缺乏症的诊断价值

Value of Growth Hormone Excise Test and Provocation Test in the Diagnosis of Children with Short Stature

【目的】评价生长激素（GH）筛查与药物联合确诊试验对儿童GH缺乏症的诊断价值。【方法】对运动试验筛查后GH低于正常值的120例矮小儿童，采用左旋多巴与胰岛素物药联合激发试验检测确诊GH缺乏，检测采用化学发光法。【结果】激发后GH在30min和60min出现最多，GH完全缺乏者占15％（18／120），部分缺乏者占29．2％（35／120），完全不缺乏者占55．8％（67／120）。【结论】药物联合确诊试验快速、准确，矮小儿童大多数是GH缺乏或部分缺乏所致。左旋多巴与胰岛素物药联合激发试验可作为临床诊断GH缺乏症的有效方法。

[Objectivel To evaluate the value of growth hormone（GH） screening and drug combination confirmed diagnosis test in the diagnosis of children with GH deficiency. [Methods] Levodopa and insulin combination provocation test was used to diagnose GH deficiency of 120 children with short stature whose the level of GH was lower than normal value after GH exercise test. Chemiluminescence method was used. [Resultsl The level of GH was the most at 30rain and 60rain after provocation. The children with complete GH deficiency occupied 15% （18/120）. The children with partial GH deficiency occupied 29.2% （35/120）. The children without GH deficiency occupied 55.8 % （67/120）. KConclusionl Drug combination confirmed di% agnosis test is rapid and accurate. Most children with short stature are caused by complete or partial GH deficiency. Levodopa and insulin combination provocation test can be used as an effective method for the clinical diagnosis of GH deficiency.