摘要
目的探讨内皮素(ET)对肺纤维化发生发展作用及其在诊断中的价值。方法利用放射免疫直接测定法,检测10例肺结节病和8例特发性肺纤维化(IPF)患者外周血和支气管肺泡灌洗液(BALF)中内皮素的含量,并与8例健康非吸烟者对照。结果肺结节病和IPF患者血浆和BALF中ET的含量分别为62.14±29.22,17.40±2.41ng/L,和76.92±21.90,10.40±3.13ng/L,均明显高于正常对照组20.08±8.37,4.04±0.55ng/L,P<0.01;研究组BALF中ET与PaO2呈负相关(r=-0.538P<0.01);BALF中ET水平与细胞总数呈正相关(r=0.649P<0.01),结节病中ET水平与淋巴细胞和IPF中ET水平与中性粒细胞有明显正相关(r=0.712P<0.01,r=0.813P<0.01)。结论ET在肺结节病和IPF发生发展中起重要的作用,并可做为判断疾病活动性的一项有用指标,为诊断提供一定的依据。
Objective To explore the role of the Endothelin (ET) in the development of interstitial lung diseases (ILD) and its signifi-cance in the diagnosis. Methods The ET level in the plasma and and Bronchial Alveolar Lavage Fluid (BALF) from 10 patients with sar-coidosis, 8 with idiopathic pulmonary fibrosis (IPF) and 8 normal non-smokers was determined using the radio-immunoassay. Results TheET level in the plasma BALF in the patients with sarcoidosis (62.14±29.22 and 17.40±2.4lng/L) and that in the IPF (76.92±71.90 and 10.40±3.13ng/L) were higher than that in 8 control normal subjects (20.08±8.37 and 4.04±0.55ng/L) p<0.01. The level of ET in the BALFwas negatively correlated With PaO_2 (r=-0.538,p<0.01). The level of ET in positively correlated with total cells in BALF (r=0.649 P<0.01).The level of ET in the BALF of the saroidosis was positively correlated with the percirentage of lymphocyte (r=0.712 p<0.01) and that inpatients with IPF was positively correlated with the percentage of neutrophil (r=0.813 p<0.01). Conclusion It was indicated that ET mightplay an important role in development of ILD. The level of ET can act as the markers of activity of the diseases and provide the basis onthe diagonsis.
出处
《中国实验诊断学》
1999年第6期271-272,共2页
Chinese Journal of Laboratory Diagnosis
基金
辽宁省科委基金!972258
关键词
内皮素
支气管肺泡
灌洗液
肺纤维化
ILD
Interstitial Lung Disease
Endothelin: Bronchial Alveolar Lavage Fluid