血浆八因子相关抗原与慢支缺氧性损害

Relationship between plama ⅧR:Ag and body hypoxic damage of chonic bronchitis in the aged

目的比较血浆八因子相关抗原（ⅧＲ：Ａｇ）和动脉血氧分压（ＰａＯ２）在反映机体缺氧性损害方面何者更为准确。方法同步测定２４例老年人慢性支气管炎（慢支）患者急性期、缓解期血浆ⅧＲ：Ａｇ和ＰａＯ２，并对两者间的关系进行统计分析。结果急性期血浆ⅧＲ：Ａｇ平均含量（３１９．９±１４．８）％与对照组（１０９．３±３０．１）％比较差异非常显著（Ｐ＜０．００１），并与ＰａＯ２呈显著负相关，ｒ＝－０．４２９，Ｐ＜０．０５。缓解期血浆ⅧＲ：Ａｇ平均含量（１２７．１±５０．７）％与对照组比较无差异（Ｐ＞０．０５），但部分病例ＰａＯ２仍小于８．０ｋＰａ且ＰａＯ２与ⅧＲ：Ａｇ无相关性，ｒ＝－０．１８４，Ｐ＞０．０５：缓解期血浆ⅧＲ：Ａｇ比急性期有非常显著的降低（Ｐ＜０．００１）。结论测定血浆ⅧＲ：Ａｇ比ＰａＯ２更能准确地反映机体缺氧性损害的严重程度。

Objective To compare one more accurately reflect body hypoxic damage,plasma ⅧR:Ag or PaO_2.Methods Plasma ⅧR: Ag and PaO_2 were simultaneously measured in 24 patients with chronic bronchitis in the acute phase and the remitting phase.Then, the results obtained were statistically analysed. Results Plasma ⅧR:Ag concentration in patients with chronic bronchitis in theacute phase (319.9±14.8) % was obviously higher (P<0.001) than that in the normal controls (109.3±30.1) %, and was negativelycorrelated with PaO_2 (r=-0.249,p<0.05). Between plasma ⅧR: Ag concentration in patients with chronic bronchitis in the remittingphase (127.1±50.7) % and that in the normal controls there was no significant diffenence (P>O.05);but PaO_2 was less than 8.0kPa inthe parts of patients with chronic bronchitis in the remitting phase and it did not correlate with plasma ⅧR:Ag (r=-0.184,P>0.05);Plasma ⅧR:Ag concentration in patients with chronic bronchitis in the remitting phase was obviously lower than that in patients inthe acture phase (P<0.001). Conclusions Plasma ⅧR:Ag could more accurately reflect body hypoxic damage than PaO_2.