自适应干扰对消的大鼠视觉诱发电位提取

The Estimation of Visual Evoked Potential in Rats based on Adaptive Interference Cancellation

研究大鼠的视觉诱发电位对认知人类视觉机理和疾病发生的位置具有重要意义。为获得大鼠视觉刺激诱发电位的特征信息,本研究设计了一种新的用于自适应干扰对消的大鼠视觉诱发电位信号采集方案,在大鼠初级视皮层不同位置和深度分别植入检测电极和干扰参考电极,有效提取了同源干扰信号。并基于该方案进行了大鼠视觉诱发电位的快速提取研究。仿真实验和实际应用结果表明,应用该方案实现自适应干扰对消,信噪比提高约6 dB,能够有效提取出大鼠单次闪光刺激诱发电位波形,并可从单次提取的结果中获得准确的潜伏期信息。该方案为实时获取大鼠视觉诱发电位特征信息提供了有效手段。

Studies on visual evoked potential （VEP） in rats can lead to a better understanding of mechanisms of human vision and the sites of disease action in humans. In this paper, a new VEP recording method for adaptive interference cancellation technique was proposed to obtain single-trial flash VEP features in rats. The corresponding electrodes were implanted in the primary visual cortex in rats. After homologous interference signal was collected and the new technique proposed was used to estimate the single-trial flash VEP in rats. The test results of simulation and experiment show that this new method can effectively extract the VEP waveform and latency information from the single-trial response and SNR is improved about 6 dB. This new method provides an effective way to obtain the real-time feature information of the VEP in rats.