NF-κB生物学特性及其在胰腺疾病中的表达研究

Biological nature of NF-κB and its expression in pancreatic diseases

NF-κB是一种具有多向调节作用的可诱导的转录因子,分布广泛,功能复杂。研究显示,NF-κB异常活化在胰腺多种疾病发生、发展过程中发挥重要作用。NF-κB亦可作为分子靶点,抑制其活性将成为胰腺疾病防治的新思路。本文概述NF-κB的生物学特性及其在胰腺疾病中的表达和意义。

Nuclear factor KB （NF-κB） is a family of inducible transcription factors that are expressed in a wide vari- ety of cells and tissues, and responsible for regulating the transcription of the expression of a large cohort of genes in- volved in innate and adaptive immunity, inflammation, cellular stress responses, cell adhesion, apoptosis and prolifera- tion. Data demonstrate that increased NF-κB activity plays a key role in the physiological and pathophysiological states of pancreatic diseases. Targeting the classical pathway of NF-κB through the inhibition of the IKK complex has been pro- posed as a useful therapeutic approach to the treatment of pancreatic diseases. In this review, we summarize the NF-κB signaling transduetion pathway and provide the current understanding of the regulation and function of this transcription factor in pancreatic diseases.