BCR/ABL转基因动物模型研究进展及应用

Research Progress and Application of BCR/ABL Transgenic Animal Model——Review

转基因动物模型为研究慢性粒系白血病的发病机理与治疗提供了一个良好平台。利用不同的启动子或四环素调控系统已建立了一系列的BCR/ABL转基因动物模型,其中相当一部分动物模型能很好的模拟人的CML特征,并在CML的发病机理与治疗的研究中广泛应用。本文就目前BCR/ABL转基因动物模型的研究进展、优缺点及应用作一综述。

Transgenic animal model provide a good platform to research the pathogenesis and therapy of chronic myelogenous leukemia（CML）.To date,a number of BCR/ABL transgenic animal models have been established using different promoter or tetracycline-controlling system.Some of them appear the characteristics of human CML,which have contributed greatly to research the pathogenesis and therapy of CML.In this article,the researching progress,advantage and drawback,application of BCR/ABL transgenic animal model are reviewed.