帕瑞昔布钠超前镇痛在鼻内镜手术中的应用

Application of parecoxib sodium for preemptive analgesia on nasal endoscopic surgery

目的:观察帕瑞昔布钠应用于鼻内镜手术超前镇痛的可行性。方法:选择择期鼻内镜手术患者63例,随机分为帕瑞昔布钠组和对照组。帕瑞昔布钠组在麻醉诱导时静脉注射帕瑞昔布钠40 mg(溶于0.9%氯化钠溶液10 mL);而对照组在相应时间内注射0.9%氯化钠溶液10 mL。分别在麻醉苏醒拔除气管导管后0.5、2、6、24 h用视觉模拟评分法(visual analogue scale,VAS)进行疼痛评分并记录手术相关并发症及药物不良反应。结果:两组患者的VAS评分在0.5 h及24 h差异无统计学意义,而在2 h和6 h时的评分差异有统计学意义(P<0.05),帕瑞昔布钠组低于对照组。结论:帕瑞昔布钠超前镇痛能缓解鼻内镜术后2～6 h疼痛程度,并降低手术并发症发生率。帕瑞昔布钠单次静脉注射行超前镇痛未见严重不良反应,安全性高。

Objective： To study the feasibility of parecoxib sodium for preemptive analgesia on nasal endoscopic surgery.Methods： Sixty-three adult patients undergoing nasal endoscopic operations were randomly divided into two groups.The patients in Group parecoxib sodium were injected intravenously with parecoxib sodium 40 mg（dissolved in 10 mL 0.9% sodium chloride） during the induction of anesthesia,and the controlled Group were instead of 10 mL 0.9% sodium chloride.The preemptive analgesia effect and side effect were evaluated with VAS scores at 0.5,2,6 and 24 h after operation.Results： VAS scores of Group parecoxib sodium were lower than the controlled Group at 2 and 6 h（P 0.05）.Conclusion： Parecoxib sodium used for preemptive analgesia in adult patients undergoing nasal endoscopic operations is effective and safe with less adverse drug reaction.