阻塞性睡眠呼吸暂停低通气综合征与胰岛β细胞功能障碍

Obstructive sleep apnea-hypopnea syndrome and beta cell dysfunction

阻塞性睡眠呼吸暂停低通气综合征（obstructive sleep apnea—hypopnea syndrome，OSAHS）是一种氧化应激性疾病，其特征性低氧方式一慢性间歇低氧诱导了机体氧化应激的产生，是累积多系统、多器官损害的病理生理基础。胰岛β细胞是最易受到氧化损伤和极易凋亡的细胞，氧化应激引起胰岛β细胞损伤是糖尿病发生、发展的重要机制。应用抗氧化剂进行预防及治疗，可能阻止、延缓OSAHS患者合并2型糖尿病的进程。

Obstructive sleep apnea-hypopnea syndrome （OSAHS） is characterized by chronic intermittent hypoxia （CIH）, the oxidative stress induced by CIH can lead to multisystem and multi-organ injury. Pancreatic β cells are vulnerable to oxidative stress, for diabetes to develop, β-cell functional impairment induced by oxidative stress is needed. Intervention with antioxidant maybe a potential therapy for pancreatic injury in patients with OSAHS.