成分输血在自体外周血干细胞移植中的应用

Application of Blood Component Transfusions in Autologous Peripheral Blood Stem Cell Transplantation

目的 探讨成分输血对恶性血液病患者自体外周血干细胞移植后的支持效果。方法 恶性血液病患者经预处理化疗及干细胞回输后，在骨髓“空虚”期当Ｈｂ＜ ８０ｇ／Ｌ 时，输注照射的浓缩红细胞；血小板＜ ２０ ×１０９／Ｌ时，输注照射的富血小板血浆，血小板输注量３ ．０ ×１０１１ 。结果 输注血小板悬液的患者，血小板计数可提高（６ ～２６）×１０９／Ｌ，维持时间为１ ～４ 天，无１ 例因血小板过低致颅内出血。结论 成份输血是自体干细胞移植后的强有力支持。

Objective To explore the supportive effect of blood component transfusions in patients malignant blood diseases receiving autologous peripheral blood stem cell transplantation (Auto PBSCT).Methods After preparative regime and stem cell transfusion,during the “vacant” phase,the irradiated packed red blood cells were transfused when Hb<80g/L;the irradiated platelet rich plasma was transfused when platelet couts<20×10 9/L,and the platelet counts needed were about 3.0×10 11 . Results Platelet counts be increased by (6～26)×10 9/L after receiving platelets and could maintain 1～4 days.No intracranal hemorrhage happened because of thrombocytopenia.Conclusion Blood component transfusions were the powerful suportive care in patients receiving auto PBSCT,among them platelet transfusion was the most important measure.