吸烟对无呼吸道症状个体肺功能的影响

Effects of smoking on pulmonary functions in individuals without respiratory symptoms

目的探讨吸烟对个体肺功能的影响。方法以吸烟、无呼吸道症状的成人个体为实验组,按照年龄±2岁、体质指数(BMI)±5%的原则,以不吸烟、且无呼吸道症状的个体(对照组)进行配对设计,分别测定并比较两组的肺功能结果。结果实验组、对照组分别纳入111例观察对象,实验组FEV1%、MVV%、MMEF%和V25%较对照组明显降低(P<0.05);而FEV1/FVC、PEF%、V75%、V50%、VC%、RV/TLC、DLCO%、Raw%及sGaw%在两组间无明显差异(P>0.05)。结论吸烟可影响个体的通气功能、通气储备功能,并增加小气道阻力。

Objective To explore the effects of smoking on pulmonary functions. Methods Data of the pulmonary functions from the study and control groups were compared. Cases in this study group were referred to adult smokers without any respiratory symptoms, while controls were selected by age ±2 years, and body mass index （BMI） ±5% to have a paired design. Results There were 111 subjects in the study and control groups respectively. Results of FEV1% , MVV% , MMEF% and V25% decreased significantly in the study group than those of controls, but there were little difference in FEV1/FVC, PEF% , V75% , V50% , VC% , RV/TLC, DLCO% , Raw% and sGaw%. Conclusion Smoking has a harmful effect on the smokers＇ventilatory function, ventilatory reserve, and increases the resistance of small airways.