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线粒体DNA遗传变异与人类环境适应性 被引量：2

Mitochondrial DNA genetic variation and human adaptation to different climate
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摘要 线粒体是真核生物细胞内的重要细胞器，处于新陈代谢和生物能量转换中心地位，在生命活动中发挥着重要作用。线粒体通过氧化磷酸化（oxidative phosphorylation, OXPHOS）产生人体用于工作的ATP和维持体温的热量，而线粒体偶联状态则决定着产生ATP和热量的相对水平。线粒体紧密偶联，
作者 郑世珍 李福祥 钱桂生 戢福云
机构地区 第三军医大学附属新桥医院全军呼吸内科研究所
出处 《中华肺部疾病杂志（电子版）》 CAS 2011年第6期55-57,共3页 Chinese Journal of Lung Diseases(Electronic Edition)
基金 国家自然科学基金(30772456) 重庆市自然基金重点项目(2009BA5055) 第三军医大学临床科研基金(2010XLC29)第三军医大学科研创新基金(2007XG57)资助
关键词 线粒体DNA 遗传变异 适应性 人类
分类号 Q523 [生物学—生物化学]
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参考文献18

  • 1Douglas C. Wallace,Jianhong Ye,S. Nicolas Neckelmann,Gurparkash Singh,Keith A. Webster,Barry D. Greenberg.Sequence analysis of cDNAs for the human and bovine ATP synthase β subunit: mitochondrial DNA genes sustain seventeen times more mutations[J]. Current Genetics . 1987 (2)
  • 2Wallace DC.Colloquium paper:bioenergetics,the origins of complexity,and the ascent of man. Proceedings of the National Academy of Sciences of the United States of America . 2010
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  • 5Wallace DC.Why do we still have a maternally inherited mitochondrial DNA?Insights from evolutionary medicine. Annual Review of Biomedical Engineering . 2007
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同被引文献27

  • 1Wheeler AP,Bernard GR. Acute lung injury and the acute respiratory distress syndrome:a clinical review[J].The Lancet,2007,(9572):1553-1564.doi:10.1016/S0140-6736(07)60604-7.
  • 2Chopra M,Reuben JS,Sharma AC. Acute lung injury:apoptosis and signaling mechanisms[J].Experimental Biology and Medicine(Maywood),2009,(04):361-371.doi:10.1093/pcp/pcq026.
  • 3Ruchko M,Gorodnya O,LeDoux SP. Mitochondrial DNA damage triggers mitochondrial dysfunction and apoptosis in oxidant-challenged lung endothelial cells[J].American Journal of Physiology-Lung Cellular and Molecular Physiology,2005,(03):L530-L535.doi:10.1152/ajplung.00255.2004.
  • 4Chouteau JM,Obiako B,Gorodnya OM. Mitochondrial DNA integrity may be a determinant of endothelial barrier properties in oxidant-challenged rat lungs[J].American Journal of Physiology-Lung Cellular and Molecular Physiology,2011,(06):L892-L898.doi:10.1152/ajplung.00210.2011.
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  • 8Ruchko MV,Gorodnya OM,Zuleta A. The DNA glycosylase Ogg1 defends against oxidant-induced mtDNA damage and apoptosis in pulmonary artery endothelial cells[J].Free Radical Biology and Medicine,2011,(09):1107-1113.doi:10.1016/j.freeradbiomed.2010.10.692.
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中华肺部疾病杂志（电子版）
2011年 第6期

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