肿瘤细胞迁移模式及其转换调控的研究进展

Research Progress of Tumor Cell Migration Strategy and the Migration Transition Mechanism

肿瘤细胞在三维培养基质中主要以两种模式迁移,即间充质式迁移(mesenchymal migration)和阿米巴式迁移(amoeboid migration)。本文总结分析了肿瘤细胞在不同迁移模式中的运动特征和不同迁移模式形成的内在动因,以及一定条件下迁移模式间相互转换的诱发因素。了解这些变化及不同迁移模式转换间的内在联系,将会加深对肿瘤细胞在不同条件下迁移特性及其过程机制的认识,进而为控制肿瘤细胞恶性转移找到更为有效的措施。

Tumor cells exhibit two main different migration strategies when invading in 3D environment, i.e. mesenchymal migration and amoeboid migration. This review summarizes the internal reasons and characteristics on various modes of migration adaptation to the microenvironment, and the molecular mechanisms in particular environment where they are mutually interchangeable. A study of the mechanisms that may possibly trigger mesenchymal-amoeboid transition/amoeboi＆mesenchymal transition help us to understand the change and the plasticity in the migration strategies of tumor cells. These are important for the development of a cancer treatment, which would efficiently suppress tumor cell invasiveness.