逐瘀通脉胶囊对糖尿病早期肾病患者胱抑素C和D二聚体的影响

The Effect of Zhuyutongmai Capsule on Early Diabetic Nephropathy in Patients with Cystatin C and D-Dimer

目的观察逐瘀通脉胶囊佐治糖尿病早期肾病的疗效,以及对胱抑素C和D二聚体的影响,并探讨其机制。方法选择78例糖尿病早期肾病患者为研究对象,均予以糖尿病饮食、运动疗法、胰岛素或(和)口服降糖药物、抗栓、调脂、ACEI或ARB制剂等常规治疗。入选后随机分为观察组和对照组,每组39例。观察组予以逐瘀通脉胶囊0.4g,3次/日,口服;对照组加服复方丹参片,3片,3次/日。疗程为12周。分别检测两组患者治疗前、后尿微量白蛋白排泄率(UAER),血清胱抑素C(CysC)和血浆D二聚体水平,并予以比较。结果①两组患者治疗后UAER、CysC、D二聚体均较前降低,差异经检验,具有统计学意义(P<0.01,P<0.05)。②观察组上述指标较之对照组降幅更甚,差异经检验,亦具有统计学意义(P<0.05)。结论逐瘀通脉胶囊对糖尿病早期肾病有一定的治疗效果,可能是通过提高肾小球滤过率,抗凝血等机制来实现的。

Objective observe the Zhuyutongmai capsule the curative effect of diabetes,and early nephropathy of employment STT C and D glutathione dimer influence,and discuss the mechanism.Methods Selection 78 cases diabetes early nephrosis patient as the research object,shall be diabetes diet,exercise therapy,insulin or/and oral glucose-lowering drugs,resistance to bolt,lipid,ACEI and arbs preparations of conventional treatment.After selected were randomly divided into observation group and control group,each group of 39 cases.The observation group be driven Zhuyutongmai capsule 0.4g,3/day,oral;The control group DanCanPian add clothing compound,3 pieces,3 / day.Treatment for 12 weeks.Two groups of patients were testing before and after treatment microalbuminuria row UAER）,shedding rates（C（STT employed serum GSH CysC） and plasma D dimers level,and to be compared.Results ①Two groups of patients after treatment CysC UAER,dimer D,which is reduced,differences before by the inspection,a statistically significant（P0.01,P0.05）.②The observation group than controls the index fell by inspection more very,differences,and has a statistical significance（P0.05）.Conclusion Zhuyutongmai capsule on diabetes early nephropathy have certain curative effect,possibly through improving glomerular filtration rate,anticoagulant mechanisms to fulfill.