结肠癌干细胞表面标志的研究和信号传导

Colon cancer stem cell surface markers and signal transduction research

背景:近年来研究表明,结肠癌干细胞参与肿瘤的复发和转移,为恶性肿瘤靶向治疗带来新的希望。目的:探讨结肠癌干细胞特异表面标志的分离和鉴定方法,以及与结肠癌干细胞研究紧密相关的信号通路。方法:以"结肠癌干细胞,肿瘤干细胞,细胞表面标志,信号传导"为中文关键词,以"colon cancer stem cell,cancer stem cell,cell surface sign,signal transduction"为英文关键词,采用计算机检索Medline和CNKI数据库2000-01/2011-06有关结肠癌干细胞表面标志和信号传导的相关文章,排除重复研究或Meta分析类文章,筛选纳入40篇文献进行评价。结果与结论:CD133+与CD44+可作结肠癌干细胞的表面标志。与结肠癌干细胞紧密相关的信号通路有Wnt和Notch等,Wnt信号通路在干细胞内环境稳定中起重要作用,Notch信号通路是干细胞信号网络的重要通路。通过研究结肠癌干细胞的表面标志,可以及早地检测出肿瘤的存在;掌握结肠癌干细胞的生物学特性和信号转导路径,可减少肿瘤的复发,为结肠癌的诊断和治疗降低难度。

BACKGROUND：In recent years,studies have shown that colon cancer stem cells are involved in tumor recurrence and metastasis,which have brought a new hope for cancer targeted therapy.OBJECTIVE：To investigate the isolation and identification method of colon cancer stem cell surface markers as well as relevant signal transduction pathways.METHODS：A computer-based search of Medline and CNKI databases（2000-01/2011-06） was performed to retrieve colon cancer stem cell surface markers and signal transduction using the keywords of ＂colon cancer stem cell,cancer stem cell,cell surface sign,signal transduction＂ in English and Chinese,respectively.Repetitive articles or Meta analyses were excluded,and finally 40 articles were included in result analysis.RESULTS AND CONCLUSION：CD133＋ and CD44＋ are used as colon cancer stem cell surface markers.Closely related to colon cancer stem cells,Wnt signaling pathway plays an important role in stem cell homeostasis,and Notch signaling pathway is a major stem cell signaling pathway.Based on studies of colon cancer stem cell surface markers,the early presence of the tumor can be detected;to grasp the biological characteristics of colon cancer stem cells and signal transduction pathway can reduce tumor recurrence,and reduce the difficulty in diagnosis and treatment of colon cancer.