心脏生物起搏器的应用进展

Research progress in biological pacemakers

背景:生物起搏器不需要更换电池,可接近磁场,对体内神经递质有自动反应性,有望成为临床治疗心脏传导系统疾病的一种有效方法。目的:从基因治疗、细胞移植、激素治疗3方面总结生物起搏器的构建方法。方法:以"生物起搏器"为检索词,应用计算机检索2000-03/2009-03万方数据库的相关文章,并限定文章语言种类为中文;同时计算机检索2000-03/2009-03PubMed数据库相关文章,检索词为"biologicalpacemaker",并限定文章语言种类为English。共检索到105篇文章,最终纳入符合标准的25篇文献进行综述。结果与结论:目前,生物起搏器的构建主要有基因转导、细胞移植与激素治疗3种方法。生物"起搏器"的研究还处于动物实验研究阶段,将它应用于临床实践中还有很多问题需要研究和解决,如怎样获得高效、安全的基因转染载体,细胞移植的最佳部位,起搏功能的调控及免疫排斥反应的处理等。随着细胞生物学、细胞电生理学、分子生物学及基因工程技术的飞速发展,现阶段存在的问题会逐步得到解决,相信心脏生物起搏器将成为临床治疗心脏传导系统疾病的一种有效方法。

BACKGROUND：Biological pacemakers need not replace battery,can approach magnetic field,and has automatic reaction to the neurotransmitter inside the body.It is an effective method to treat cardiac conduction system disease.OBJECTIVE：From gene treatment,cell transplantation,hormone curing to acquaint the methods of building biological pacemakers.METHODS：Using ＂biological pacemaker＂ as a keyword in Chinese and English,a computer-based search of Wanfang and PubMed databases（2000-03/2009-03） was conducted to retrieve relevant articles.Among the 105 retrieved articles,25 articles were included in result analysis.RESULTS AND CONCLUSION：Currently,there are three kinds of methods to build biological pacemakers：gene transfection,cell transplantation and hormone cure.The research of biological pacemaker is still placed in the animal experimental step,and it has a long way to go until the biological pacemakers can be used clinically,such as how to acquire safe and efficient gene vectors,the best part for cell transplantation,how to adjust the pacing function and how to handle the immunity reject reaction,etc.We believe according to the developing of cell biology,cell electricity physiology,molecular biology and genetic engineering technology,the problems that exist currently will gradually be settled and biologic pacemakers will become an effective way to treat cardiac conduction system disease.