异体骨基质明胶颗粒骨水泥复合牛骨形态发生蛋白修复兔挠骨缺损

Rabbits' radius segmental bone defect repaired with the compound materials of BMG particles impregnated with bone cement and bBMP

探讨异体骨基质明胶颗粒、骨水泥作为bBMP载体及释放系统修复兔烧骨缺损的成骨方式及诱导成骨能力．方法：复合材料及自体骨分别移植于成年新西兰兔烧骨基准大小骨缺损，术后不同时期进行X线、组织形态学、ECT，扫描电镜观察，比较复合材料修复骨缺损的方式及能力．结果：复合材料修复成年新西兰兔挠骨基准大小骨缺损，与新鲜自体骨移植相比，修复程度及愈合率无显著差异；复合材料和新鲜自体骨移植的愈合过程及成骨方式相同．结论：异体骨基质明胶颗粒、骨水泥是bBMP的良好载体，两者复合后有良好诱导成骨能力，用于修复兔挠骨缺损，效果良好．

AIM: To investigate the osteogenesis and the formof new bone formation in repairing bone defect using the com-pound materials of the allogenic bone matrix gelatin (BMG)particles, impregnated with polymethyl-methacrylate (PM-MA) bone cement and bovine bone morphogenetic proteins(bBMP). METHODS: The compound materials and autolo-gous bone were implanted in New Zealand rabbits' radiusbone defects respectively. The samp1es were observed withgross, X-ray, single photo emission computed tomography(SPECT), histomorphological and scanning electronic micro-scope at different periods after operation in order to observethe form of new bone formation and osteogenesis of the com-pound materials in contrast to autaiogous bone. RESULTS:@ There was no significant deference in the healing rate be-tween the compound materials and autologous bone. @ Thecompound material graft was similar to the fresh autologousbone graft in the healing process and the form.of new boneformation. CONCLUS1ON: Allogenic BMG particles impreg-nated with bone cement act as a good bBMP slow releasingcarriers and the compound materials possess a superior boneinduction. The resu1ts of rabbits' radius bone defect repairedwith the compound materials are satisfactory.