白介素-18在急性心肌梗死患者冠脉血管病变中的浓度表达及临床意义探讨

Study on clinical significance of serum level of interleukin-18 in patients with acute myocardial infarction

目的探讨白介素-18在急性心肌梗死(AMI)患者冠脉血管病变程度中的浓度变化及临床意义。方法 61例AMI患者,酶联免疫吸附法(ELISA)测定IL-18浓度,选择性冠状动脉造影确定冠状动脉狭窄程度,根据造影结果分单支组、双支组和3支组。设20例健康体检人员为对照组。结果 AMI组IL-18显著高于与对照组(P<0.01);3支组于入院时、24 h、72 h和7 d后均显著高于单支组和双支组(P<0.01),双支组在入院时高于单支组(P<0.01),在72 h和7 d后双支组显著高于单支(P<0.01)。结论 AMI患者血IL-18水平显著升高,其升高的程度与冠状动脉病变的狭窄程度有相关性,IL-18浓度对判断急性心肌梗死病变严重性有重要的参考价值。

Objective To study the changes in serum level of interleukin-18（IL-18） in patients with acute myocardial infarction（AMI） and its clinical significance.Methods Serum level of IL-18 was determined by enzyme linked immunosorbent assay（ELISA）,61 cases underwent selective coronary angiography were divided into groups with single vessel lesion,double vessel lesions and triple vessel lesions.Results Serum level of IL-18 in patients with AMI was significantly higher than that of control group（P0.01）,IL-18 in triple vessel lesions was significantly higher than that of single vessel lesion and double vessel lesions on admission,24 h,72 h and 7th day of hospitalization.Serum level of IL-18 in patients with double vessel lesions was higher than that of patients with single vessel lesion on admission（P0.01）,and it was significantly higher at 72 hours and on 7th day（P0.01）.Conclusion Serum level of IL-18 is significantly elevated in patients with AMI,and serum level of IL-18 is correlated with the severity of coronary atherosclerosis.It has important reference value in evaluation of the severity of AMI.