孕妇血清中转铁蛋白、铁蛋白、叶酸和维生素B_(12)测定与优生的相关性研究

The relation of serum levels of transferring,ferritin,folic acid and vitamin B_(12) in pregnant women to the eugenic

目的通过检测孕妇血清转铁蛋白、铁蛋白、叶酸和维生素B12的含量,探讨转铁蛋白、铁蛋白、叶酸和维生素B12与优生的相关性。方法收集150例妊娠期的妇女及30例健康非妊娠妇女的血清标本,在全自动生化分析仪上用免疫比浊法测定血清中转铁蛋白,用化学发光免疫分析方法检测血清铁蛋白、叶酸和维生素B12的含量。结果血清叶酸和维生素B12含量随孕期增长逐渐降低。早孕期孕妇血清中叶酸和维生素B12含量与对照组妇女相比较,无显著性差异。中孕期及晚孕期妇女血清叶酸和维生素B12含量与对照组妇女相比较,显著低于对照组。新生儿体质量与母体叶酸和B12含量呈正相关;在早、中、晚期妊娠中,转铁蛋白铁蛋白含量显著低于对照组;而转铁蛋白含量在早、中、晚期妊娠均显著高于对照组。结论优生与孕妇转铁蛋白、铁蛋白、血清叶酸和维生素B12有相关性。测定孕妇血清中转铁蛋白、铁蛋白、叶酸和维生素B12含量,可判断孕妇是否存在营养缺乏,并可了解胎儿营养、生长状况,为尽早干预治疗提供依据。

Objective To investigate the relation between the serum levels of transferring,ferritin,folic acid and vitamin B12 in pregnant women and the eugenic.Methods Serum specimens were collected from pregnant（150） and non-pregnant women（30） respectively.Serum transferrin was detected with immunoturbidimetry on automatic biochemistry analyzer,ferritin,folic acid and vitamin B12 were detected with chemiluminescence immunoassay.Results Serum folic acid and vitamin B12 contents were gradually decreased with gestation.There was no significant difference in the levels of serum folic acid and vitamin B12 between women in their first trimester of pregnancy and control subjects;however serum folic acid and vitamin B12 were significantly lower in middle and late pregnancy than in control.Neonatal body weight was positively correlated with the levels of folic acid and B12.Ferritin level was significantly lower.Conclusion Serum levels of transferring,ferritin,folic acid and vitamin B12 are related to eugenics.Detection oferum transferring,ferritin,folic acid and vitamin B12 may help to determine whether alimentary deficiency exists in pregnant women,understand fetal nutrition and growth status,and provide the basis for corresponding early intervention therapy.