2型糖尿病合并非酒精性脂肪肝患者同型半胱氨酸及血脂特点分析

The relationship between homocysteine,dyslipidemia and nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus

目的探讨在2型糖尿病(T2DM)合并非酒精性脂肪性肝病患者中检测空腹血清同型半胱氨酸(tHCY)的临床意义。方法将210例2型糖尿病患者分为不合并非酒精性脂肪性肝病组(A组)108例,合并非酒精性脂肪性肝病组(B组)102例,分别测定身高、体质量,抽空腹血检查同型半胱氨酸(tHCY)、总胆固醇(TC)、甘油三脂(TG)、高密度脂蛋白(HDL-C)及低密度脂蛋白(LDL-C)等,计算体质指数(BMI)。结果 B组的BMI、TG、TC、LDL-C及tHCY均明显高于A组(P<0.05)。而年龄,HDL-C明显小于A组(P<0.01),tHCY与BMI、TG、TC、LDL-C、HDL-C的相关分析:tHCY与TG﹙r=0.245,P<0.05﹚、BMI﹙r=0.216,P<0.05﹚、LDL-C﹙r=0.223,P<0.05﹚呈正相关,与HDL-C呈负相关﹙rs=-0.222,P<0.05﹚。结论血脂紊乱及血清同型半胱氨酸是T2DM合并非酒精性脂肪性肝病的危险因素,并且TG、BMI、HDL-C及LDL-C与血清同型半胱氨酸水平具有相关性。

Objective To investigate the clinical significance of serum total homocysteine（tHCY） examination in type 2 diabetes mellitus（T2DM） complicated with nonalcoholic fatty liver disease（NAFLD）.Methods 310 patients with T2DM were divided into group A（102 with NAFLD） and group B（108 without NAFLD）.Body height,body weight,tHCY,total cholesterol（TC）,triglyceride（TG）,high density lipoprotein（HDL-C） and low density lipoprotein（LDL-C） were measured.Body mass index（BMI） was calculated.Results The levels of BMI,TG,TC,LDL-C,and tHCY in T2DM patients with NAFLD were significantly higher than those in T2DM patients without NAFLD（P0.05）.However,the levels of age and HDL-C were significantly lower than those in T2DM patients without NAFLD（P0.01）.The level of tHCY was positively correlated with TG（rs=0.245,P0.05）,BMI（rs= 0.216,P0.05）,LDL-C（rs=0.223,P0.05）,and was negatively correlated with HDL-C（rs=-0.243,P0.05）.Conclusion The level of tHCY and blood lipid disorder are risk factors in T2DM with NAFLD.The levels of TG,BMI,HDL-C and LDL-C are correlated with tHCY.