超敏C反应蛋白在冠心病诊断中的临床意义

Clinical Significance of hs-CRP in Diagnoses of Coronary Disease

目的:探讨超敏C反应蛋白(hs-CRP)在冠心病诊断中的临床意义。方法:对入选患者稳定性心绞痛(SA)组31例、不稳定性心绞痛(UA)组27例、急性心肌梗死(AMI)组26例,共84例及正常对照组35例,用免疫透射比浊法测定其血浆中hs-CRP水平,以观察其相关性。结果:SA组血hs-CRP含量与正常对照组比较,差异无统计学意义(P>0.05);UA组hs-CRP含量与正常对照组比较,差异有统计学意义(P<0.05);AMI组血hs-CRP含量与正常对照组比较,差异有统计学意义(P<0.01)。在冠心病组中hs-CRP阳性率明显高于传统检测项目CK及CK-MB的阳性率。结论:冠心病患者血清hs-CRP的增高与冠心病的发生发展显著相关,并有助于冠心病的早期诊断和预后判断,它是心血管事件危险因素之一。

Objectives:To investigate the clinical significance of high sensitivity C-reactive protein(hs-CRP)in diagnoses of coronary disease.Methods:119 patients were enrolled in the study,of whom 31 with stable angina pectoris(SA),27 with unstable angina pectoris(UA),26 of them with acute myocardial infartion(AMI),the others patients without coronary disease were assigned to control group.Hs-CRP was determined by immune transmission turbidity.Result of each group was analysed.Results:Hs-CRP of patients with UA and AMI were significantly higher than that of control group(P<0.05 or P<0.01).Hs-CRP of patients with SA was higher than that of control group,But,there was no statistical significance between them(P>0.05).Positive rate of hs-CPR in patients with coronary disease was 76.2%,which was higher than positive rates of CK and CK-MB.Conclusions:Hs-CRP of patients with coronary disease was closely related to occurrence and development of coronary disease.Determination of hs-CRP was useful for early diagnosis and prediction of the prognosis of patients with coronary disease.