帕罗西汀治疗功能性消化不良的临床观察

Comparative Study of Motion Stimulant in Treatment of Functional Dyspepsia

目的:探讨应用帕罗西汀治疗功能性消化不良(FD)的疗效及安全性。方法:将276例病程大于1年的功能性消化不良患者,随即分为3组,甲组93例单独给予帕罗西汀治疗;乙组90例应用内科常规治疗(抑酸药和/或促胃动力药);丙组93例给予乙组治疗+帕罗西汀联合治疗。结果:甲丙两组间比较差异无统计学意义;乙组治疗有效率与甲丙两组比较,差异有非常统计学意义。并提示:应用抗抑郁药至少和内科常规治疗相当,甚至有所超越,联用抗抑郁药和内科常规治疗药并不比单独应用抗抑郁药优越。结论:应用帕罗西汀能有效治疗FD,且不良反应少而轻。

Objective:To explore the effect of the treatment on patients with functional dyspepsia(FD).Methods:276 patients with FD were divided into 3 groups: group A(n=93) received motion stimulant;group B(n=90) was given routine medicine treatment,psycho pharmaceutical treatment,including antidepressants,anxiolytics and antipsychotic;group C(n=93),psychopharmaceutical treatment pulsing psychotherapy.Results:While there was no significant difference between group A and group C,there was a significant difference in group C compared with group A and group B.Conclusion:Motion stimulant is very effective for the treatment of functional dyspepsia.