病原DNA识别及其诱导天然免疫调节机制研究进展

The Cellular Recognition of Pathogenic DNA and The Related Regulation of Innate Immunity

机体天然免疫系统拥有一系列可以探测和抵制微生物侵袭的机制.目前,关于病原RNA的细胞内识别机制有了较为深入的研究和相关报道,但细胞内病原DNA的识别和相应的天然免疫应答机制仍未完全被揭示.阐明上述机制有助于了解和治疗一系列微生物感染相关的疾病,包括病毒和细菌感染类疾病、病毒相关的肿瘤、自身免疫性疾病等.近年来,细胞内多个充当"DNA传感器"的分子和干扰素调节分子被认为在细胞质DNA诱导宿主天然免疫反应过程中起着关键性调节作用.综述了对细胞内病原DNA的主要识别分子、信号通路以及相关的天然免疫调控机制.

The innate immune system may be the first defence line to detect and counter viral and microbial invasion.There are many mechanisms working in innate system,which would be helpful to understand the pathogenesis of infectious diseases,virus-related cancers and autoimmune diseases.Despite of the understanding about the recognition signaling in response to cellular RNA,the recognition mechanisms and related innate immunological response of pathogen DNA still remain largely unclear.Recently,a few molecules in the cell were discovered to function as DNA sensors which play key roles during DNA mediated IFN production.Besides,some molecules that could regulate IFN signaling were isolated and shown to be critical for DNA mediated innate immunity.Recent progress about the detection and recognition of pathogenic DNA,as well as its regulation of innate immunity were summarized.