血清超敏C-反应蛋白水平与冠心病的关系探讨

Detection of high sensitive c-reaction protein in patients with coronary heart disease

目的探讨冠心病(CHD)患者超敏C反应蛋白(HS-CRP)水平差异及其与血脂的关系。方法 138例冠心病和164例冠脉造影正常的非冠心病患者,分别测定了HS-CRP、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、胆固醇(TC)和低密度脂蛋白胆固醇(LIDL-C)血清水平,并进行相关性分析。结果 CHD组血清HS-CRP水平为(4.77±3.24)mg/L,与非CHD组的(2.72±1.43)mg/L相比较,差异无统计学意义(P=0.068),但CHD组高HS-CRP水平发生率(44.93%)远高于非CHD组(19.51%)(P<0.01);HS-CRP与TG具有相关性(r=0.551,P=0.003)最强。结论冠心病患者可能存在隐性炎症;HS-CRP检测对了解冠心病患者血管内皮功能有一定的意义。

Objective To detect the level of HS - CRP in patients with coronary heart disease(CHD),and its relations to other risk factors.Methods The serum levels of high - sensitive CRP(HS - CRP) in patients with CHD and non -CHD were measured by immunoturbidimetry,while triglycer ide(TG),high - density lipoprotein cholesterol(HDL - C),total cholesterol(TC),low -density lipoprotein cholesterol(LDL - C) were measured by enzymatic analysis.Results There were no statistical differences between serum levels of HS - CRP in CHD and non - CHD(P =0.068),but the percentage of patients with high HS - CRP in patients with CHD were much higher than those in non - CHD(P <0.01 ).HS - CRP was more relative to TG than other risk factors(r =0.551,P =0.003).Conclusion The patients with CHD may exsit potential in flammation.HS - CRP can be regarded as an independent risk factor of CHD,and detection of HS - CRP have diagnostic value to understand vascular epithelial function in patients with CHD.