降钙素原与真菌血流感染的相关性研究

Research on relativity between procalcitonin and fungal bloodstream infection

目的分析降钙素原(PCT)与真菌血流感染的相关性,研究不同真菌感染PCT的差异及PCT与疾病预后的关系。方法回顾性分析2009年1月-2010年12月血液培养真菌感染的患者33例,结合其PCT的检测结果,与随机抽取的100例血液培养阴性患者作统计学分析,研究真菌血流感染与PCT的相关性,同时分析不同真菌感染时PCT结果的差异及感染预后与PCT的相关性。结果 33例血液真菌感染患者中,检出假丝酵母菌属感染18例,隐球酵母菌属感染7例,荚膜组织胞浆菌及球孢子菌感染各4例;PCT<0.5ng/L者5例,PCT>2ng/L者23例,100例血液培养阴性的患者中,PCT<0.5ng/L者83例,PCT>2ng/L者9例,按行×列表的χ2检验,χ2=17.79,查χ2界值表,得P<0.05,认为血流真菌感染时,PCT的检测结果有统计学意义;采用单因素方差分析的统计学方法研究不同真菌感染时PCT的检测均数,计算F值=3.341,查F界值表,得P>0.05,表明不同真菌感染时,PCT的检测结果差异无统计学意义;采用t检验的方法研究有效控制和死亡患者PCT的检测均数,t=-2.989,查t界值表,得P<0.01,表明真菌血流感染患者的预后与PCT的检测结果明显相关。结论重视PCT的检测结果,结合患者感染症状,及时有效的控制真菌感染非常必要。

OBJECTIVE To analyze the relativity between procalcitonin and blood fungus infection,study the difference of PCT of different fungus infection and the connections between PCT and the prognosis. METHODS A total of 33 cases of blood fungus infection patients were analyzed,according to PCT value,and statistically compared to 100 patients with negative blood culture.The relativity between blood fungus infection and PCT was studied and the difference of PCT when different fungus infect and the connecstudied and the difference of PCT when different fungus infect and the connection between PCT and the prognosis were analyzed at the same time, RESULTS There were 18 infections caused by candida, 7 by eryptococcu,, 4 by Hlstoplasma capsulatum,4 By cocci spore bacteria in the 33 blood fungus iafeetions; and there were 5cases with, PCT〈0.5 ng/L, 23 eases with PCT〉2 ng/L, There were 8a cases with PCT〈0, 5 ng/L and 9 cases with PCT 〉2 ng/L in the 100 patients with negative blood culture. According to row×line ssay,χ^2= 17, 79, we could see p〈0, 05 by χ^2 extent list, We could believe that the PCT result had statistical significance when blood fungus infection occurred, The PCT mean value of different fungus infection was studied by one-way ANCIVA, F=a. 341,P〉0, 05, which indicated that the PET reau!t was not relative to the c;χ^2aategory of fungus. The PCT mean value of effective cure and die patients were studied by t-assay, t=-2.89, p%0, 0l,whi0h indicated that PCT was strongly relative to prognosis of blood fungus infection, CONCLUGION It is essentiOl for us to attach importance to PCT detection in order tO control the fungal infection timely and effectively,