氯吡格雷联合阿司匹林对ACS患者行PCI术的疗效及抗感染作用

Efficacy of double dose of clopidogrel combined with aspirin in ACS patients undergoing PCI and its anti-infection

目的观察双倍剂量氯吡格雷联合阿司匹林在行经皮冠状动脉介入治疗(PCI)急性冠脉综合征(ACS)患者中的疗效和抗感染作用。方法对于ACS患者PCI术后血栓并发症高危患者168例,随机分为3组,观察组使用双倍负荷量和双倍维持量(共2周)的氯吡格雷,3组患者术前每天均服用阿司匹林100mg(>1周),手术当天服用300mg,术后给予100mg维持;术后给予药物治疗,并观察术后30d内心血管死亡、心肌梗死、心绞痛、脑卒中、休克等心血管事件和出血并发症的发生。结果 30d内A组仅发生心血管事件2例(3.6%),为复发性缺血症和心肌梗死;与B、C组相比效果显著,差异有统计学意义(P<0.05)。结论对于ACS患者PCI术后血栓并发症高危患者给予双倍剂量的氯吡格雷后,心血管事件和出血发生较少,术后无感染病例发生。

OBJECTIVE To observe the double dose of clopidogrel combined with aspirin in patients with acute coronary syndrome in patients undergoing PCI and the efficacy of anti-infective effects. METHODS A total of 168 patients with thrombosis for ACS after PCI at high risk of complications in 168 eases were randomly divided into observation and control groups, observation groups using double load and double maintenance dose （2 weeks） of clopidogrel, three groups of patients before taking aspirin every day 100 mg （〉 1 week）, operation taking 300 mg the same day, after giving 100mg maintained. Postoperative medication therapy and observation on postoperative cardiovascular within 30 days myocardial infarction, death, angina, cardiovascu haemorrhage complications of. RESULTS Only 2 case （3.6 %） was occurred with lar event of stroke, shock and cardiovascular events （ 2.4 % ）, for patients with recurrent ischemia. Compared with the b, c, group achieved significant results, with statistically significant （P〈0.05）. CONCLUSION For ACS patients with thrombosis after PCI at high risk of complications after giving a double dose of clopidogrel, less and less cardiovascular events and hemorrhage occur, and there is no infection case occurred after operation.